node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCM55755.1 | SCM55762.1 | MWSIV6_0138 | MWSIV6_0142 | Hypothetical Protein. | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.686 |
SCM55755.1 | SCM55763.1 | MWSIV6_0138 | MWSIV6_0143 | Hypothetical Protein. | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | 0.431 |
SCM55755.1 | mtiP | MWSIV6_0138 | MWSIV6_0140 | Hypothetical Protein. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.846 |
SCM55755.1 | rtcB | MWSIV6_0138 | MWSIV6_0141 | Hypothetical Protein. | tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Binds 2 manganese ions per subunit. steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with re [...] | 0.806 |
SCM55755.1 | wrbA | MWSIV6_0138 | MWSIV6_0139 | Hypothetical Protein. | Multimeric flavodoxin WrbA. | 0.866 |
SCM55762.1 | SCM55755.1 | MWSIV6_0142 | MWSIV6_0138 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Hypothetical Protein. | 0.686 |
SCM55762.1 | SCM55763.1 | MWSIV6_0142 | MWSIV6_0143 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | 0.544 |
SCM55762.1 | mtiP | MWSIV6_0142 | MWSIV6_0140 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.763 |
SCM55762.1 | rtcB | MWSIV6_0142 | MWSIV6_0141 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Binds 2 manganese ions per subunit. steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with re [...] | 0.997 |
SCM55762.1 | wrbA | MWSIV6_0142 | MWSIV6_0139 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Multimeric flavodoxin WrbA. | 0.680 |
SCM55763.1 | SCM55755.1 | MWSIV6_0143 | MWSIV6_0138 | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | Hypothetical Protein. | 0.431 |
SCM55763.1 | SCM55762.1 | MWSIV6_0143 | MWSIV6_0142 | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.544 |
SCM55763.1 | mtiP | MWSIV6_0143 | MWSIV6_0140 | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.442 |
SCM55763.1 | rtcB | MWSIV6_0143 | MWSIV6_0141 | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Binds 2 manganese ions per subunit. steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with re [...] | 0.478 |
SCM55763.1 | wrbA | MWSIV6_0143 | MWSIV6_0139 | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | Multimeric flavodoxin WrbA. | 0.434 |
mtiP | SCM55755.1 | MWSIV6_0140 | MWSIV6_0138 | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Hypothetical Protein. | 0.846 |
mtiP | SCM55762.1 | MWSIV6_0140 | MWSIV6_0142 | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.763 |
mtiP | SCM55763.1 | MWSIV6_0140 | MWSIV6_0143 | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Region of a membrane-bound protein predicted to be embedded in the membrane; Hypothetical protein. | 0.442 |
mtiP | rtcB | MWSIV6_0140 | MWSIV6_0141 | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Binds 2 manganese ions per subunit. steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with re [...] | 0.943 |
mtiP | wrbA | MWSIV6_0140 | MWSIV6_0139 | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Multimeric flavodoxin WrbA. | 0.850 |