STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
crtDCarotenoid 3,4-desaturase {ECO:0000303|}; Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR). CrtD is involved in the desaturation reactions that form double bonds at C-3,4 of dihydroisopentenyldehydrorhodopin (DH-IDR) and C-3',4' of dihydrobisanhydrobacterioruberin (DH-BABR) to yield isopentenyld ehydrorhodopin (IDR) and bisanhydrobacterioruberin (BABR), respectively. isopentenyldehydrorhodopin + reduced acceptor. bisanhydrobacterioruberin + reduced acceptor. and DH-BABR. family; sp|A0A0A1GKA2|CRTD_HALJP;evalue=1e-109; PctID=40.86; score=397. (495 aa)    
Predicted Functional Partners:
crtB
Phytoene synthase; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Name=ATP; Xref=ChEBI:CHEBI:30616; Evidence=; Note=ATP is required for the transferase activity but it does not seem to be hydrolyzed during the reaction; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; sp|P54977|CRTB_STRGR;evalue=4e-015; PctID=39.64; s [...]
 
  
 0.984
lye
Lycopene elongase; Involved in bacterioruberin biosynthesis. Catalyzes the addition of 2 isoprene units to lycopene to generate tetrahydrobisanhydrobacterioruberin. protein and unlike in H.salinarum, Lye is not regulated by bacterioopsin; sp|D4GTV9|LYEL_HALVD;evalue=1e-034; PctID=32.50; score=147.
 
  
 0.959
SCM56122.1
Phytoene synthase {ECO:0000313|EMBL:AAB86274,1}; tr|O27836|O27836_METTH;evalue=8e-014; PctID=86.67; score=82.0.
  
  
 0.944
SCM56126.1
Phytoene synthase related protein {ECO:0000313|EMBL:ADL57979,1}; tr|D9PUT2|D9PUT2_METTM;evalue=6e-031; PctID=75.00; score=139.
  
  
 0.944
cruF
Bisanhydrobacterioruberin hydratase {ECO:0000303|}; Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR). Catalyzes the reaction that introduces hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin (BABR) to generate BR. 2 H(2)O. protein; sp|A0A0A1GNF2|CRUF_HALJP;evalue=6e-016; PctID=36.49; score=84.7.
 
   
 0.742
idsA
Short chain isoprenyl diphosphate synthase; sp|Q53479|IDSA_METTM;evalue=3e-143; PctID=81.23; score=508; Belongs to the FPP/GGPP synthase family.
  
  
 0.719
SCM56483.1
Putative cobalamin binding protein {ECO:0000313|EMBL:ADL58169,1}; tr|D9PVC1|D9PVC1_METTM;evalue=1e-130; PctID=68.96; score=473.
 
  
 0.691
SCM58193.1
Digeranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
 
  
 0.637
phr
Deoxyribodipyrimidine photo-lyase; Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. residues (in DNA). Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit; Name=oxidized coenzyme F420; Xref=ChEBI:CHEBI:57922; Note=Binds 1 coenzyme F420 non-covalently per subunit; sp|P12769|PHR_METTH;evalue=0.0; PctID=69.91; score=653.
 
  
 0.627
SCM57015.1
Magnesium-chelatase subunit ChlI homolog; sp|Q58321|Y911_METJA;evalue=7e-103; PctID=56.85; score=375.
  
  
 0.587
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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