Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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pyrGCTP synthase {ECO:0000255|HAMAP-Rule:MF_01227}; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)    
Predicted Functional Partners:
guaAB
GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP.
  
 
 0.966
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.947
rps2
30S ribosomal protein S2; sp|O26150|RS2_METTH;evalue=8e-107; PctID=96.46; score=385; Belongs to the universal ribosomal protein uS2 family.
  
 
 0.925
nrdD
Anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme. Together the two form an alpha-2/beta-2 heterodimer; Hypothetical protein.
    
 0.918
rpl13-2
Fused L13/S9 ribosomal protein; L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity). the 30S ribosomal subunit (By similarity). protein L13P family. protein S9P family. ribosomal subunit, and that they are not known to contact each other in the ribosome, this may be incorrectly predicted and should perhaps be two separate genes; sp|O26146|RLSX_METTH;evalue=1e-054; PctID=81.20; score=211.
 
 
 0.910
rpl13-1
Fused L13/S9 ribosomal protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.895
argS
Arginine-tRNA ligase; sp|O27496|SYR_METTH;evalue=0.0; PctID=83.75; score=955; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.895
rpoB1
DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.887
rpl1
50S ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
  
 
 0.839
rpoB2
DNA-directed RNA polymerase subunit B'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The B (B''+B' and beta) subunits have been implicated in DNA promoter recognition and also in nucleotide binding. + RNA(n+1). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; subunits: A',A'',B' and B''; sp|P09844|RPOB2_METTW;evalue=0.0; PctID=96.12; score=970.
  
 
 0.834
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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