STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCM57273.1Putative protein {ECO:0000313|EMBL:ADL58587,1}; tr|D9PWI9|D9PWI9_METTM;evalue=3e-064; PctID=55.11; score=251. (230 aa)    
Predicted Functional Partners:
cofC
2-phospho-L-lactate guanylyltransferase {ECO:0000255|HAMAP-Rule:MF_02114}; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
       0.861
thiDE
Thiamine biosynthesis bifunctional protein ThiED; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate. methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphomethyl)pyrimidine. (phosphomethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphomethyl)pyrimidine. [...]
       0.861
proS
Proline-tRNA ligase {ECO:0000255|HAMAP-ECO:0000305}; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
       0.844
SCM57267.1
UPF0179 protein; sp|P72011|Y609_METTH;evalue=2e-059; PctID=73.29; score=227; Belongs to the UPF0179 family.
       0.534
egsA
Glycerol-1-phosphate dehydrogenase [NAD(P)+]; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
       0.534
rpiA
Ribose-5-phosphate isomerase A {ECO:0000255|HAMAP-Rule:MF_00170}; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
       0.511
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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