STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ogt2Methylated-DNA-protein-cysteine methyltransferase {ECO:0000255|HAMAP-Rule:MF_00772}; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and ove [...] (151 aa)    
Predicted Functional Partners:
SCM57294.1
Hypothetical protein.
       0.757
mre11
DNA double-strand break repair protein Mre11 {ECO:0000255|HAMAP-Rule:MF_02044}; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
  
 0.735
SCM58590.1
Putative N-glycosylase/DNA lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion (By similarity). apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate; sp|O27397|OGG1_METTH;evalue=2e-126; PctID=69.68; score=452.
  
  
 0.732
SCM57292.1
Cl-channel voltage-gated family protein {ECO:0000313|EMBL:AEG19383,1}; tr|F6D6F0|F6D6F0_METPW;evalue=2e-129; PctID=60.66; score=469.
     
 0.682
glgC
Glucose-1-phosphate adenylyltransferase; Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans. diphosphate + ADP-glucose. adenylyltransferase family; Hypothetical protein.
     
 0.622
SCM57297.1
Sensory transduction histidine kinase {ECO:0000313|EMBL:AAB85125,1}; tr|O26716|O26716_METTH,tr|T2GHE9|T2GHE9_9EURY; evalue=1e-060; PctID=49.14; score=239.
       0.601
pdtaS9
Putative sensor histidine kinase pdtaS; Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR (By similarity). phospho-L-histidine; sp|P9WGL4|PDTAS_MYCTO,sp|P9WGL5|PDTAS_MYCTU; evalue=1e-008; PctID=25.84; score=62.0.
       0.601
nth-2
Endonuclease III {ECO:0000255|HAMAP-Rule:MF_00942}; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
   
 0.600
uvrC
UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203}; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
     
 0.575
uvrB
UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204}; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is foun [...]
     
 0.574
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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