STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vorCKetoisovalerate oxidoreductase subunit VorC; sp|P80909|VORC_METTM;evalue=6e-031; PctID=75.64; score=132. (79 aa)    
Predicted Functional Partners:
vorB
Ketoisovalerate oxidoreductase subunit VorB; sp|O26800|VORB_METTH;evalue=8e-167; PctID=84.24; score=586.
 
 
 0.996
vorA
Ketoisovalerate oxidoreductase subunit VorA; sp|P80907|VORA_METTM;evalue=0.0; PctID=82.53; score=794.
 
 
 0.995
Acsm3
Acyl-coenzyme A synthetase ACSM3, mitochondrial; Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy-and 2,3-or 3,4-unsaturated acids (in vitro) (By similarity). + an acyl-CoA. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; family; sp|Q6SKG1|ACSM3_RAT;evalue=6e-122; PctID=39.89; score=438.
 
  
 0.940
ilvE
Putative branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
    
  0.903
SCM57449.1
Putative transcriptional regulator {ECO:0000313|EMBL:ADL58682,1}; tr|D9PWT4|D9PWT4_METTM;evalue=4e-093; PctID=93.41; score=346.
 
  
 0.897
tfrA
Fumarate reductase (CoM/CoB) subunit A; Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB-CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen. Binds 1 flavin covalently per subunit. methanogenic Archaea, composed of subunits A (TfrA) and B (TfrB); Hypothetical protein.
  
 
 0.877
gatD
Glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
 
    0.872
gatE
Glutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
       0.835
hndA
NADH dehydrogenase; Catalyzes the reduction of NADP in the presence of molecular H(2) to yield NADPH. HndA and HndB could form a heterodimeric intermediate in the electron transfer between the active site of hydrogenase subunit HndD and the NADP reduction site of the reducing subunit HndC; Hypothetical protein.
   
 
 0.823
korA1
2-oxoglutarate synthase subunit KorA; sp|Q57724|KORA_METJA;evalue=3e-037; PctID=32.22; score=157.
  
  
 0.682
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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