STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slc9b2Mitochondrial sodium/hydrogen exchanger 9B2; Electroneutral exchange of protons for Na(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity; Multi-pass membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5BKR2-1; Name=2; IsoId=Q5BKR2-2; Sequence=VSP_033155; Note=No experimental confirmation available.; Name=3; IsoId=Q5BKR2-3; Sequence=VSP_033154; Note=No experimental confirmation available.; buds, in mandible, maxilla, occipital bone, clavicle and femu [...] (388 aa)    
Predicted Functional Partners:
smbP2
DNA helicase, putative. The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases; Hypothetical protein.
   
 
 0.813
kefC
Glutathione-regulated potassium-efflux system protein KefC {ECO:0000255|HAMAP-Rule:MF_01413}; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Rule:MF_01413}; Multi-pass membrane protein (CPA2) transporter (TC 2.A.37) family. KefC subfamily. Rule:MF_01413}; sp|B4TJ42|KEFC_SALHS;evalue=9e-052; PctID=26.73; score=205.
   
 
 0.670
mgtA
Cation-transporting ATPase (P-type); This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. + Ca(2+)(Side 2); Multi-pass membrane protein Sarcoplasmic reticulum membrane; Multi-pass membrane protein Note=Colocalizes with SclA and SclB at the sarcoplasmic reticulum (SR) and the dyad, a structure in which the SR membrane lies closest to both the plasma membrane and the sarcomeres; Hypothetical protein.
   
 0.659
yloB
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. + Ca(2+)(Side 2). after onset of sporulation. germinate at a slower rate. (TC 3.A.3) family. Type IIA subfamily; sp|O34431|ATCL_BACSU;evalue=2e-078; PctID=40.00; score=294.
   
 0.659
ctpF
Putative cation-transporting ATPase F; sp|P63688|CTPF_MYCBO,sp|P9WPS8|CTPF_MYCTO, sp|P9WPS9|CTPF_MYCTU;evalue=3e-015; PctID=26.32; score=80.9.
   
 0.659
SCM58008.1
Calcium-transporting ATPase lmo0841; Catalyzes the hydrolysis of ATP coupled with the transport of calcium. The transport is electrogenic with a probable ATP:Ca(2+):H(+) stoichiometry of 1:1:1. May have an important role in survival of the bacterium when stressed by a combination of a high calcium concentration and alkaline pH. + Ca(2+)(Side 2). vanadate. ATPase activity is stimulated by Sr(2+). Inhibited by very high concentrations of cyclopiazonic acid (CPA). pH dependence: Optimum pH is 9.0; ECO:0000269|}; Multi-pass membrane protein (TC 3.A.3) family. Type IIA subfamily; sp|Q8Y8Q5| [...]
   
 0.659
yfiL1
Putative ABC transporter ATP-binding protein YfiL; sp|P94440|YFIL_BACSU;evalue=2e-048; PctID=35.71; score=193.
 
 0.621
yfiL3
Putative ABC transporter ATP-binding protein YfiL; sp|P94440|YFIL_BACSU;evalue=2e-052; PctID=35.10; score=206.
 
 0.621
drrA
Daunorubicin resistance ABC transporter ATP-binding subunit; ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation; Hypothetical protein.
 
 0.619
SCM58481.1
Putative cation transporter MJ1485; sp|Q58880|Y1485_METJA;evalue=5e-085; PctID=37.88; score=315.
   
 
 0.618
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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