close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiNThiamine-phosphate synthase ThiN; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate. thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thi [...] (186 aa)    
Predicted Functional Partners:
thiDE
Thiamine biosynthesis bifunctional protein ThiED; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate. methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphomethyl)pyrimidine. (phosphomethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphomethyl)pyrimidine. [...]
   
 0.991
thiL
Thiamine-monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_02128}; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
     
 0.927
SCM58126.1
Nucleoside-triphosphatase THEP1 {ECO:0000255|HAMAP-Rule:MF_00796}; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
  
  
  0.913
frlB
Catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine. 6-phosphate + L-lysine. glucose 6-phosphate and lysine from fructoselysine: step 2/2. ProRule:PRU00797}. Sequence=AAA58168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Evidence=; sp|P0AC00|FRLB_ECOLI,sp|P0AC01|FRLB_SHIFL;evalue=9e-024; PctID=28.76; score=111.
       0.867
SCM57749.1
Putative protein MTH_862; sp|O26950|Y862_METTH;evalue=1e-063; PctID=75.00; score=241.
       0.589
SCM56196.1
Conserved protein {ECO:0000313|EMBL:AAB86314,1}; tr|O27876|O27876_METTH;evalue=4e-096; PctID=54.08; score=358.
  
     0.555
Thi4
Ribose 1,5-bisphosphate isomerase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
 
   
 0.508
hcp
Hydroxylamine reductase {ECO:0000255|HAMAP-Rule:MF_00069}; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
 
     0.493
pyrI
Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase.
 
     0.491
SCM57334.1
Putative protein MJ0206; sp|Q57659|Y206_METJA;evalue=3e-029; PctID=46.32; score=127.
  
     0.434
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.