STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
carACarbamoyl-phosphate synthase small chain {ECO:0000255|HAMAP-Rule:MF_01209}; sp|O27079|CARA_METTH;evalue=2e-166; PctID=82.10; score=585; Belongs to the CarA family. (360 aa)    
Predicted Functional Partners:
carB
Carbamoyl-phosphate synthase large chain; sp|O27077|CARB_METTH;evalue=0.0; PctID=91.22; score=1906; Belongs to the CarB family.
 0.999
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
 0.999
pyrB
Aspartate carbamoyltransferase; sp|O27464|PYRB_METTH;evalue=1e-136; PctID=81.67; score=485.
 
 0.999
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.995
pyrE
Orotate phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_01208}; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
  
 0.994
pyrD
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate.
 
  
 0.991
pyrK
Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
  
 0.987
ddl
D-alanine-D-alanine ligase {ECO:0000255|HAMAP-Rule:MF_00047}; Cell wall formation. alanyl-D-alanine. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit; Rule:MF_00047}; sp|B0TVX5|DDL_FRAP2;evalue=8e-010; PctID=26.11; score=65.1.
  
 0.985
purF
Amidophosphoribosyltransferase{ECO:0000255|HAMA P-Rule:MF_01931}; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.978
argF
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. + L-citrulline. arginine from L-ornithine and carbamoyl phosphate: step 1/3; sp|O27495|OTC_METTH;evalue=7e-144; PctID=84.28; score=509; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
   
  0.978
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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