STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCM58226.1Putative ATP-binding protein MJ0823; sp|Q58233|Y823_METJA;evalue=3e-057; PctID=48.07; score=221. (275 aa)    
Predicted Functional Partners:
cdhC
Acetyl-CoA decarbonylase/synthase complex subunit beta {ECO:0000255|HAMAP-Rule:MF_01138}; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.
 
  
 0.892
cdhE
Acetyl-CoA decarbonylase/synthase complex subunit gamma {ECO:0000255|HAMAP-Rule:MF_01136}; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
 
  
 0.889
cdhD
Acetyl-CoA decarbonylase/synthase complex subunit delta {ECO:0000255|HAMAP-Rule:MF_01135}; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.
 
  
 0.883
SCM58228.1
Putative protein {ECO:0000313|EMBL:ADL59083,1}; tr|D9PXY5|D9PXY5_METTM;evalue=4e-021; PctID=74.65; score=106.
       0.861
serS
Type-2 serine-tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
       0.848
cdhA5
Acetyl-CoA decarbonylase/synthase complex subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 7 [4Fe-4S] clusters per heterotetramer; Name=[Ni-Fe-S] cluster; Xref=ChEBI:CHEBI:60400; Evidence=; Note=Binds 2 [Ni-Fe-S] clusters per heterotetramer.; ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential). cluster C is a mixed Ni-Fe-S c [...]
 
  
 0.736
SCM58233.1
Putative protein {ECO:0000313|EMBL:AAB85612,1}; tr|O27195|O27195_METTH;evalue=1e-034; PctID=60.87; score=151.
       0.658
cdhE2
Acetyl-CoA decarbonylase/synthase complex subunit gamma 2; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. tetrahydrosarcinapterin = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin. Name=corrinoid; Xref=ChEBI:CHEBI:33913; Evidence=; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster; is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential); sp|Q [...]
  
     0.626
cdhB-2
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably has a structural role in stabilizing the alpha-epsilon subcomponent of the ACDS complex by forming a structural link between the two alpha subunits. ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8). Rule:MF_01134}; sp|O27744|ACDE_METTH;evalue=3e-037; PctID=47.53; score=154.
 
    0.566
cdhA1
Acetyl-CoA decarbonylase/synthase complex subunit alpha; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
 
  
 0.562
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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