STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.972
pyrB
Aspartate carbamoyltransferase; Catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.931
carA
Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.924
AT05_03275
Dihydroorotase; Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.860
AT05_09175
Uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.857
AT05_11455
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 
 0.857
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.841
AT05_00175
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
 
 0.840
AT05_01795
D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.800
AT05_06260
Orotate phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.794
Your Current Organism:
Schleiferia thermophila
NCBI taxonomy Id: 1453500
Other names: S. thermophila str. Yellowstone, Schleiferia thermophila str. Yellowstone
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