STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THI1-2Thiamine thiazole synthase, chloroplastic; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; B [...] (351 aa)    
Predicted Functional Partners:
THI1
Thiamine thiazole synthase, chloroplastic; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; B [...]
  
  
 
0.900
MNEG_5229
Hydroxymethylpyrimidine kinase.
  
  
 0.815
MNEG_0471
Uncharacterized protein; Belongs to the peptidase C1 family.
      
 0.559
MNEG_2799
TPK_B1_binding domain-containing protein.
     
 0.510
MNEG_2180
Isocitrate lyase.
      
 0.495
MNEG_16351
Nudix hydrolase 20.
      
 0.465
MNEG_9433
Putative allantoin permease.
      
 0.418
MNEG_14483
Adenosine kinase.
     
 0.413
MNEG_14484
Adenosine kinase.
     
 0.413
MNEG_12689
Uncharacterized protein.
     
 0.413
Your Current Organism:
Monoraphidium neglectum
NCBI taxonomy Id: 145388
Other names: M. neglectum, Monoraphidium neglectum Heynig & Krienitz, SAG 48.87
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