guaA protein (Rathayibacter toxicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

guaA

GMP synthetase; Catalyzes the synthesis of GMP from XMP. (524 aa)

Predicted Functional Partners:

ALS56941.1

0.999

guaB

0.999

argS

0.996

rplK

0.993

pyrG

0.988

apt

0.986

ALS57510.1

0.986

lysS

0.982

tuf

0.980

gmk

0.977

Your Current Organism:

Rathayibacter toxicus

NCBI taxonomy Id: 145458
Other names: ATCC 49908, CIP 104617, Clavibacter toxicus, DSM 7488, ICMP 9525, JCM 9669, NCPPB 3552, R. toxicus, strain CS14

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS56941.1	guaA	APU90_03470	APU90_03450	Guanosine monophosphate reductase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.999
ALS56941.1	guaB	APU90_03470	APU90_03475	Guanosine monophosphate reductase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.983
ALS56941.1	pyrG	APU90_03470	APU90_01795	Guanosine monophosphate reductase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.703
ALS56941.1	tuf	APU90_03470	APU90_03795	Guanosine monophosphate reductase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.440
ALS57510.1	apt	APU90_06795	APU90_02730	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.900
ALS57510.1	gmk	APU90_06795	APU90_10040	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.929
ALS57510.1	guaA	APU90_06795	APU90_03450	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.986
ALS57510.1	guaB	APU90_06795	APU90_03475	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.521
apt	ALS57510.1	APU90_02730	APU90_06795	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
apt	gmk	APU90_02730	APU90_10040	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.956
apt	guaA	APU90_02730	APU90_03450	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.986
apt	guaB	APU90_02730	APU90_03475	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.521
argS	guaA	APU90_09055	APU90_03450	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.996
argS	lysS	APU90_09055	APU90_06700	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	lysine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.795
argS	pyrG	APU90_09055	APU90_01795	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.742
argS	rplK	APU90_09055	APU90_07335	arginyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.461
gmk	ALS57510.1	APU90_10040	APU90_06795	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
gmk	apt	APU90_10040	APU90_02730	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.956
gmk	guaA	APU90_10040	APU90_03450	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthetase; Catalyzes the synthesis of GMP from XMP.	0.977
gmk	guaB	APU90_10040	APU90_03475	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.473