ALS57228.1 protein (Rathayibacter toxicus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ALS57228.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (337 aa)

Predicted Functional Partners:

ALS57227.1

0.775

ALS57229.1

0.701

ALS57452.1

0.479

ALS57656.1

0.448

Your Current Organism:

Rathayibacter toxicus

NCBI taxonomy Id: 145458
Other names: ATCC 49908, CIP 104617, Clavibacter toxicus, DSM 7488, ICMP 9525, JCM 9669, NCPPB 3552, R. toxicus, strain CS14

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS57227.1	ALS57228.1	APU90_05130	APU90_05135	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.775
ALS57227.1	ALS57229.1	APU90_05130	APU90_05140	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.701
ALS57228.1	ALS57227.1	APU90_05135	APU90_05130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775
ALS57228.1	ALS57229.1	APU90_05135	APU90_05140	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.701
ALS57228.1	ALS57452.1	APU90_05135	APU90_06445	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.479
ALS57228.1	ALS57656.1	APU90_05135	APU90_07650	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.448
ALS57229.1	ALS57227.1	APU90_05140	APU90_05130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.701
ALS57229.1	ALS57228.1	APU90_05140	APU90_05135	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.701
ALS57452.1	ALS57228.1	APU90_06445	APU90_05135	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.479
ALS57452.1	ALS57656.1	APU90_06445	APU90_07650	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.915
ALS57656.1	ALS57228.1	APU90_07650	APU90_05135	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.448
ALS57656.1	ALS57452.1	APU90_07650	APU90_06445	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.915

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.863

expected number of edges:

10

PPI enrichment p-value:

0.0387

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

5 of 136

1.71

1.79

9.30e-05

GO:0032787

Monocarboxylic acid metabolic process

6 of 316

1.43

1.51

9.30e-05

GO:0006637

acyl-CoA metabolic process

3 of 50

1.93

1.27

0.0032

GO:0000038

Very long-chain fatty acid metabolic process

2 of 11

2.41

1.2

0.0062

GO:0009150

Purine ribonucleotide metabolic process

4 of 216

1.42

1.04

0.0036

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016790

Thiolester hydrolase activity

5 of 34

2.32

3.61

6.27e-08

GO:0008474

Palmitoyl-(protein) hydrolase activity

3 of 7

2.78

2.48

2.83e-05

GO:0047617

acyl-CoA hydrolase activity

2 of 9

2.5

1.12

0.0090

GO:0016788

Hydrolase activity, acting on ester bonds

6 of 576

1.17

1.06

0.00048

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18735

Mixed, incl. Thiolester hydrolase activity, and Thioesterase superfamily

6 of 30

2.45

4.98

1.11e-10

CL:18753

acyl-CoA hydrolase activity, and Palmitoyl hydrolase activity

3 of 6

2.85

2.5

2.67e-05

CL:18772

Mixed, incl. Phospholipase/carboxylesterase/thioesterase, and 1-acylglycerophosphoserine O-acyltransferase activity

3 of 7

2.78

2.49

2.67e-05

CL:17449

Protein import into peroxisome matrix, docking, and Pex, N-terminal

2 of 17

2.22

0.85

0.0267

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01040

Biosynthesis of unsaturated fatty acids

4 of 67

1.93

2.22

1.93e-05

map01212

Fatty acid metabolism

3 of 103

1.61

1.14

0.0037

map00680

Methane metabolism

2 of 34

1.92

1.01

0.0110

map00030

Pentose phosphate pathway

2 of 46

1.79

0.96

0.0126

map00564

Glycerophospholipid metabolism

3 of 173

1.39

0.87

0.0110

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

4 of 25

2.35

2.85

3.07e-06

MAP-2046104

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

4 of 25

2.35

2.85

3.07e-06

MAP-389887

Beta-oxidation of pristanoyl-CoA

4 of 28

2.3

2.82

3.07e-06

MAP-193368

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

4 of 41

2.14

2.64

4.79e-06

MAP-390918

Peroxisomal lipid metabolism

4 of 48

2.07

2.52

6.95e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 187

1.48

0.97

0.0072

GOCC:0005782

Peroxisomal matrix

2 of 20

2.15

0.78

0.0366

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02551

Acyl-CoA thioesterase

2 of 2

3.15

1.31

0.0044

PF03959

Serine hydrolase (FSH1)

2 of 7

2.61

1.04

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042171

Acyl-CoA thioesterase, double hotdog domain

2 of 2

3.15

1.06

0.0126

IPR003703

Acyl-CoA thioesterase

2 of 2

3.15

1.06

0.0126

IPR003140

Phospholipase/carboxylesterase/thioesterase

2 of 2

3.15

1.06

0.0126

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