ALS57382.1 protein (Rathayibacter toxicus) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ALS57382.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)

Predicted Functional Partners:

ALS57383.1

0.773

ALS57384.1

0.470

ALS57385.1

0.470

pyrE

0.411

ALS57387.1

0.411

ALS57388.1

0.411

Your Current Organism:

Rathayibacter toxicus

NCBI taxonomy Id: 145458
Other names: ATCC 49908, CIP 104617, Clavibacter toxicus, DSM 7488, ICMP 9525, JCM 9669, NCPPB 3552, R. toxicus, strain CS14

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS57382.1	ALS57383.1	APU90_06030	APU90_06035	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
ALS57382.1	ALS57384.1	APU90_06030	APU90_06040	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.470
ALS57382.1	ALS57385.1	APU90_06030	APU90_06045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.470
ALS57382.1	ALS57387.1	APU90_06030	APU90_06055	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.411
ALS57382.1	ALS57388.1	APU90_06030	APU90_06060	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.411
ALS57382.1	pyrE	APU90_06030	APU90_06050	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).	0.411
ALS57383.1	ALS57382.1	APU90_06035	APU90_06030	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
ALS57383.1	ALS57384.1	APU90_06035	APU90_06040	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.506
ALS57383.1	ALS57385.1	APU90_06035	APU90_06045	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.506
ALS57383.1	ALS57387.1	APU90_06035	APU90_06055	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.433
ALS57383.1	ALS57388.1	APU90_06035	APU90_06060	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.572
ALS57383.1	pyrE	APU90_06035	APU90_06050	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).	0.598
ALS57384.1	ALS57382.1	APU90_06040	APU90_06030	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.470
ALS57384.1	ALS57383.1	APU90_06040	APU90_06035	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.506
ALS57384.1	ALS57385.1	APU90_06040	APU90_06045	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.822
ALS57384.1	ALS57387.1	APU90_06040	APU90_06055	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.661
ALS57384.1	ALS57388.1	APU90_06040	APU90_06060	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.665
ALS57384.1	pyrE	APU90_06040	APU90_06050	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).	0.661
ALS57385.1	ALS57382.1	APU90_06045	APU90_06030	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.470
ALS57385.1	ALS57383.1	APU90_06045	APU90_06035	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.506

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006281

DNA repair

6 of 56

1.37

1.54

3.20e-05

GO:0090305

Nucleic acid phosphodiester bond hydrolysis

6 of 64

1.31

1.45

3.36e-05

GO:0006259

DNA metabolic process

8 of 136

1.11

1.23

9.62e-06

GO:0090304

Nucleic acid metabolic process

10 of 267

0.91

0.96

3.47e-06

GO:0044260

Cellular macromolecule metabolic process

9 of 334

0.77

0.7

8.40e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004527

Exonuclease activity

5 of 21

1.72

2.16

7.64e-06

GO:0140097

Catalytic activity, acting on DNA

8 of 70

1.4

2.06

6.80e-08

GO:0140664

ATP-dependent DNA damage sensor activity

3 of 8

1.91

1.49

0.0010

GO:0008408

3-5 exonuclease activity

3 of 10

1.82

1.41

0.0013

GO:0008094

ATP-dependent activity, acting on DNA

4 of 26

1.53

1.36

0.00065

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990391

DNA repair complex

3 of 8

1.91

1.48

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:375

DNA-directed DNA polymerase activity, and Exonuclease

5 of 15

1.86

2.54

1.90e-06

CL:373

Mixed, incl. DNA replication, and Base excision repair

6 of 30

1.64

2.32

8.72e-07

CL:371

Mixed, incl. Catalytic activity, acting on DNA, and DDH domain

7 of 48

1.5

2.16

3.71e-07

CL:378

Mixed, incl. AAA domain, and PIN-like domain superfamily

3 of 5

2.12

1.73

0.00043

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lalw03410

Base excision repair

3 of 10

1.82

1.34

0.0019

lalw03440

Homologous recombination

3 of 24

1.44

0.91

0.0091

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

3 of 18

1.56

0.82

0.0200

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0234

DNA repair

4 of 30

1.46

1.17

0.0018

KW-0227

DNA damage

4 of 30

1.46

1.17

0.0018

KW-0235

DNA replication

3 of 20

1.52

0.99

0.0069

KW-0239

DNA-directed DNA polymerase

2 of 6

1.86

0.85

0.0228

KW-0540

Nuclease

3 of 36

1.26

0.71

0.0228

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