STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa)    
Predicted Functional Partners:
SD78_3207
Acetolactate synthase large subunit.
 
 
 0.999
SD78_3208
Acetolactate synthase small subunit.
 
 
 0.999
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.998
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
  
 0.995
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.989
SD78_4051
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 
 0.989
SD78_0405
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 
 0.988
SD78_0846
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 
 0.988
SD78_0040
Acetolactate synthase large subunit; Belongs to the TPP enzyme family.
 
 
 0.985
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.980
Your Current Organism:
Bacillus badius
NCBI taxonomy Id: 1455
Other names: ATCC 14574, B. badius, Bacillus encimensis, Bacillus encimensis Dastager et al. 2015, Bacillus sp. SGD-V-25, CCUG 7412, CIP 58.52, DSM 23, DSM 28241 [[Bacillus encimensis]], IFO 15713, JCM 12228, LMG 7122, LMG:7122, NBRC 15713, NCIB 9364, NCIB:9364, NCIM 5513, NCTC 10333, NRRL NRS-663, VKM B-496, strain SGD-V-25 [[Bacillus encimensis]]
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