STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvGAcetolactate synthase isozyme 2 large subunit; Belongs to the TPP enzyme family. (547 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase isozyme 3 small subunit.
 0.988
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.967
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.945
alsS
Acetolactate synthase; Belongs to the TPP enzyme family.
  
  
 
0.926
ilvI
Acetolactate synthase isozyme 3 large subunit.
  
  
 
0.925
psdht_1
Phenylserine dehydratase.
  
 0.916
tdcB_1
L-threonine dehydratase catabolic TdcB.
  
 0.916
tdcB_2
L-threonine dehydratase catabolic TdcB.
  
 0.916
bfmBAB
2-oxoisovalerate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.876
leuA_2
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.874
Your Current Organism:
Octadecabacter temperatus
NCBI taxonomy Id: 1458307
Other names: DSM 26878, LMG 27946, LMG:27946, O. temperatus, Octadecabacter sp. SB1, Octadecabacter temperatus Billerbeck et al. 2015, strain SB1
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