STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BG58_00245Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)    
Predicted Functional Partners:
secY
Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
     
 0.717
ffh
Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belo [...]
   
 
  0.641
BG58_00255
Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.623
secA
Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.
    
  0.557
BG58_00595
Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.525
BG58_00250
Glutathione S-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.496
BG58_00240
DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.455
Your Current Organism:
Caballeronia jiangsuensis
NCBI taxonomy Id: 1458357
Other names: Burkholderia jiangsuensis, Burkholderia jiangsuensis Liu et al. 2014, Burkholderia sp. MP-1, C. jiangsuensis, Caballeronia jiangsuensis (Liu et al. 2014) Dobritsa and Samadpour 2016, LMG 27927, LMG:27927, MCCC 1K00250, strain MP-1
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