node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RMCB_1425 | RMCB_3435 | RMCB_1425 | RMCB_3435 | HAD-superfamily hydrolase. | Phosphoesterase PA-phosphatase related protein. | 0.527 |
RMCB_1425 | RMCB_4336 | RMCB_1425 | RMCB_4336 | HAD-superfamily hydrolase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.756 |
RMCB_1425 | RMCB_4517 | RMCB_1425 | RMCB_4517 | HAD-superfamily hydrolase. | Cystathionine beta-synthase CBS. | 0.713 |
RMCB_1425 | hisB | RMCB_1425 | RMCB_1888 | HAD-superfamily hydrolase. | Imidazoleglycerol-phosphate dehydratase. | 0.628 |
RMCB_1425 | hisE | RMCB_1425 | RMCB_4342 | HAD-superfamily hydrolase. | phosphoribosyl-ATP pyrophosphatase. | 0.532 |
RMCB_1425 | hisF | RMCB_1425 | RMCB_1892 | HAD-superfamily hydrolase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.718 |
RMCB_1425 | hisH | RMCB_1425 | RMCB_1889 | HAD-superfamily hydrolase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.660 |
RMCB_1425 | hisI | RMCB_1425 | RMCB_1893 | HAD-superfamily hydrolase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.625 |
RMCB_1425 | priA | RMCB_1425 | RMCB_1890 | HAD-superfamily hydrolase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.631 |
RMCB_1425 | serC | RMCB_1425 | RMCB_0681 | HAD-superfamily hydrolase. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.619 |
RMCB_3435 | RMCB_1425 | RMCB_3435 | RMCB_1425 | Phosphoesterase PA-phosphatase related protein. | HAD-superfamily hydrolase. | 0.527 |
RMCB_4336 | RMCB_1425 | RMCB_4336 | RMCB_1425 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | HAD-superfamily hydrolase. | 0.756 |
RMCB_4336 | RMCB_4517 | RMCB_4336 | RMCB_4517 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-synthase CBS. | 0.944 |
RMCB_4336 | hisI | RMCB_4336 | RMCB_1893 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.441 |
RMCB_4336 | priA | RMCB_4336 | RMCB_1890 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase hisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.413 |
RMCB_4336 | serC | RMCB_4336 | RMCB_0681 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.431 |
RMCB_4517 | RMCB_1425 | RMCB_4517 | RMCB_1425 | Cystathionine beta-synthase CBS. | HAD-superfamily hydrolase. | 0.713 |
RMCB_4517 | RMCB_4336 | RMCB_4517 | RMCB_4336 | Cystathionine beta-synthase CBS. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.944 |
RMCB_4517 | serC | RMCB_4517 | RMCB_0681 | Cystathionine beta-synthase CBS. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.871 |
hisB | RMCB_1425 | RMCB_1888 | RMCB_1425 | Imidazoleglycerol-phosphate dehydratase. | HAD-superfamily hydrolase. | 0.628 |