node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RMCB_0275 | RMCB_4816 | RMCB_0275 | RMCB_4816 | Alpha-ketoglutarate decarboxylase. | Dihydrolipoamide dehydrogenase. | 0.999 |
RMCB_0275 | gcvH | RMCB_0275 | RMCB_1297 | Alpha-ketoglutarate decarboxylase. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.950 |
RMCB_0275 | gcvH-2 | RMCB_0275 | RMCB_4820 | Alpha-ketoglutarate decarboxylase. | Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.950 |
RMCB_0275 | gcvP-2 | RMCB_0275 | RMCB_4822 | Alpha-ketoglutarate decarboxylase. | Glycine dehydrogenase subunit beta; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.976 |
RMCB_0275 | gcvT | RMCB_0275 | RMCB_4821 | Alpha-ketoglutarate decarboxylase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.922 |
RMCB_0275 | glyA-2 | RMCB_0275 | RMCB_4819 | Alpha-ketoglutarate decarboxylase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.821 |
RMCB_0275 | lipA | RMCB_0275 | RMCB_4817 | Alpha-ketoglutarate decarboxylase. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.539 |
RMCB_0275 | lipB | RMCB_0275 | RMCB_7062 | Alpha-ketoglutarate decarboxylase. | Lipoate biosynthesis protein B lipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.538 |
RMCB_4816 | RMCB_0275 | RMCB_4816 | RMCB_0275 | Dihydrolipoamide dehydrogenase. | Alpha-ketoglutarate decarboxylase. | 0.999 |
RMCB_4816 | RMCB_4818 | RMCB_4816 | RMCB_4818 | Dihydrolipoamide dehydrogenase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.782 |
RMCB_4816 | RMCB_4823 | RMCB_4816 | RMCB_4823 | Dihydrolipoamide dehydrogenase. | Uncharacterized protein. | 0.554 |
RMCB_4816 | gcvH | RMCB_4816 | RMCB_1297 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.908 |
RMCB_4816 | gcvH-2 | RMCB_4816 | RMCB_4820 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system, H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.970 |
RMCB_4816 | gcvP-2 | RMCB_4816 | RMCB_4822 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase subunit beta; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.970 |
RMCB_4816 | gcvT | RMCB_4816 | RMCB_4821 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.973 |
RMCB_4816 | glyA-2 | RMCB_4816 | RMCB_4819 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
RMCB_4816 | lipA | RMCB_4816 | RMCB_4817 | Dihydrolipoamide dehydrogenase. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.890 |
RMCB_4816 | lipB | RMCB_4816 | RMCB_7062 | Dihydrolipoamide dehydrogenase. | Lipoate biosynthesis protein B lipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.400 |
RMCB_4818 | RMCB_4816 | RMCB_4818 | RMCB_4816 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Dihydrolipoamide dehydrogenase. | 0.782 |
RMCB_4818 | RMCB_4823 | RMCB_4818 | RMCB_4823 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Uncharacterized protein. | 0.554 |