STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (929 aa)    
Predicted Functional Partners:
RMCB_5337
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
 0.974
pckG
Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
     
 0.947
pgk
Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
  
 
 0.945
RMCB_0669
Type II citrate synthase; Belongs to the citrate synthase family.
     
 0.934
RMCB_1251
Phosphoenolpyruvate synthase.
     
 0.933
glcB
Malate synthase G glcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
     
 0.933
RMCB_3687
Citrate synthase I gltA1; Belongs to the citrate synthase family.
     
 0.931
RMCB_0673
Citrate synthase 2; Belongs to the citrate synthase family.
     
 0.929
eno
Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 
 0.928
RMCB_1913
Pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.927
Your Current Organism:
Mycolicibacterium brisbanense
NCBI taxonomy Id: 146020
Other names: ATCC 49938, CCUG 47584, DSM 44680, JCM 15654, M. brisbanense, Mycobacterium brisbanense, Mycobacterium brisbanense Schinsky et al. 2004, Mycobacterium genomospecies 4, Mycolicibacterium brisbanense (Schinsky et al. 2004) Gupta et al. 2018, strain W6743
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.