KCV82575.1 protein (Actibacterium atlanticum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

KCV82575.1

Hypothetical protein; COG3071 Uncharacterized enzyme of heme biosynthesis. (522 aa)

Predicted Functional Partners:

KCV82574.1

0.900

KCV82573.1

0.750

KCV81152.1

0.727

KCV82957.1

0.721

KCV82552.1

0.713

KCV83537.1

0.708

ftsQ

0.688

KCV82570.1

0.650

KCV80797.1

0.649

KCV82183.1

0.646

Your Current Organism:

Actibacterium atlanticum

NCBI taxonomy Id: 1461693
Other names: A. atlanticum, Actibacterium atlanticum Li et al. 2015, Actibacterium sp. 22II-S11-z10, LMG 27158, LMG:27158, MCCC 1A09298, strain 22II-S11-z10

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCV80797.1	KCV82552.1	ATO10_15280	ATO10_06406	Lipoprotein.	Exonuclease-like protein; COG3893 Inactivated superfamily I helicase.	0.477
KCV80797.1	KCV82575.1	ATO10_15280	ATO10_06521	Lipoprotein.	Hypothetical protein; COG3071 Uncharacterized enzyme of heme biosynthesis.	0.649
KCV80797.1	KCV83537.1	ATO10_15280	ATO10_02215	Lipoprotein.	Hypothetical protein.	0.732
KCV80797.1	ftsQ	ATO10_15280	ATO10_00090	Lipoprotein.	Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.	0.761
KCV81152.1	KCV82575.1	ATO10_13264	ATO10_06521	Hypothetical protein.	Hypothetical protein; COG3071 Uncharacterized enzyme of heme biosynthesis.	0.727
KCV81152.1	KCV82957.1	ATO10_13264	ATO10_05087	Hypothetical protein.	Hypothetical protein; COG0500 SAM-dependent methyltransferases.	0.477
KCV82183.1	KCV82575.1	ATO10_07332	ATO10_06521	COG3216 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG3071 Uncharacterized enzyme of heme biosynthesis.	0.646
KCV82183.1	ftsQ	ATO10_07332	ATO10_00090	COG3216 Uncharacterized protein conserved in bacteria.	Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.	0.429
KCV82552.1	KCV80797.1	ATO10_06406	ATO10_15280	Exonuclease-like protein; COG3893 Inactivated superfamily I helicase.	Lipoprotein.	0.477
KCV82552.1	KCV82574.1	ATO10_06406	ATO10_06516	Exonuclease-like protein; COG3893 Inactivated superfamily I helicase.	Hypothetical protein.	0.645
KCV82552.1	KCV82575.1	ATO10_06406	ATO10_06521	Exonuclease-like protein; COG3893 Inactivated superfamily I helicase.	Hypothetical protein; COG3071 Uncharacterized enzyme of heme biosynthesis.	0.713
KCV82552.1	ftsQ	ATO10_06406	ATO10_00090	Exonuclease-like protein; COG3893 Inactivated superfamily I helicase.	Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.	0.695
KCV82570.1	KCV82573.1	ATO10_06496	ATO10_06511	YCII-like domain-containing protein; COG2350 Uncharacterized protein conserved in bacteria.	uroporphyrinogen-III synthase.	0.714
KCV82570.1	KCV82574.1	ATO10_06496	ATO10_06516	YCII-like domain-containing protein; COG2350 Uncharacterized protein conserved in bacteria.	Hypothetical protein.	0.607
KCV82570.1	KCV82575.1	ATO10_06496	ATO10_06521	YCII-like domain-containing protein; COG2350 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG3071 Uncharacterized enzyme of heme biosynthesis.	0.650
KCV82573.1	KCV82570.1	ATO10_06511	ATO10_06496	uroporphyrinogen-III synthase.	YCII-like domain-containing protein; COG2350 Uncharacterized protein conserved in bacteria.	0.714
KCV82573.1	KCV82574.1	ATO10_06511	ATO10_06516	uroporphyrinogen-III synthase.	Hypothetical protein.	0.852
KCV82573.1	KCV82575.1	ATO10_06511	ATO10_06521	uroporphyrinogen-III synthase.	Hypothetical protein; COG3071 Uncharacterized enzyme of heme biosynthesis.	0.750
KCV82574.1	KCV82552.1	ATO10_06516	ATO10_06406	Hypothetical protein.	Exonuclease-like protein; COG3893 Inactivated superfamily I helicase.	0.645
KCV82574.1	KCV82570.1	ATO10_06516	ATO10_06496	Hypothetical protein.	YCII-like domain-containing protein; COG2350 Uncharacterized protein conserved in bacteria.	0.607

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

10

PPI enrichment p-value:

8.91e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015940

Pantothenate biosynthetic process

3 of 7

2.58

1.81

0.00046

GO:0072330

Monocarboxylic acid biosynthetic process

4 of 111

1.5

1.04

0.0051

GO:0019752

Carboxylic acid metabolic process

6 of 554

0.98

0.67

0.0090

GO:0044281

Small molecule metabolic process

8 of 1051

0.83

0.64

0.0028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 22

2.08

1.27

0.0037

GO:0004029

Aldehyde dehydrogenase (NAD+) activity

2 of 8

2.34

0.77

0.0397

GO:0003824

Catalytic activity

11 of 4151

0.37

0.26

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13320

Coenzyme A biosynthesis, and Pantothenate metabolic process

4 of 12

2.47

2.91

2.87e-06

CL:13321

Pantothenate metabolic process, and Ketopantoate reductase PanE/ApbA

3 of 6

2.65

2.31

5.28e-05

CL:13126

Mixed, incl. Metabolism of nucleotides, and Vitamin biosynthetic process

5 of 109

1.61

1.77

5.28e-05

CL:11098

acetate-CoA ligase activity, and Aldehyde dehydrogenase family

2 of 6

2.47

1.06

0.0117

CL:10969

Mixed, incl. Valine, leucine and isoleucine degradation, and Peroxisomal lipid metabolism

3 of 80

1.52

0.76

0.0270

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00770

Pantothenate and CoA biosynthesis

6 of 49

2.03

3.87

1.65e-09

map00410

beta-Alanine metabolism

3 of 33

1.91

1.69

0.00035

map01110

Biosynthesis of secondary metabolites

7 of 812

0.88

0.78

0.00035

map01100

Metabolic pathways

11 of 2836

0.54

0.46

9.74e-05

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