STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (552 aa)    
Predicted Functional Partners:
nadD
Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.970
ppnK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.947
cobB-2
COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily.
    
 0.936
KCV83143.1
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.911
KCV83735.1
Competence/damage-inducible protein CinA; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family.
    
 0.894
KCV81199.1
NADH pyrophosphatase; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding.
  
 
 0.874
KCV83108.1
COG0531 Amino acid transporters.
    
 0.873
pntA
NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.
     
 0.873
KCV82390.1
Glutamate synthase (NADPH) large subunit; COG0067 Glutamate synthase domain 1.
    
 0.873
KCV81178.1
COG0686 Alanine dehydrogenase; Belongs to the AlaDH/PNT family.
  
 
  0.835
Your Current Organism:
Actibacterium atlanticum
NCBI taxonomy Id: 1461693
Other names: A. atlanticum, Actibacterium atlanticum Li et al. 2015, Actibacterium sp. 22II-S11-z10, LMG 27158, LMG:27158, MCCC 1A09298, strain 22II-S11-z10
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