KCV81105.1 protein (Actibacterium atlanticum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

KCV81105.1

COG4227 Antirestriction protein. (310 aa)

Predicted Functional Partners:

KCV81106.1

0.943

KCV81123.1

0.932

KCV81107.1

0.880

KCV81102.1

0.730

KCV81103.1

0.713

KCV81104.1

0.665

KCV81046.1

0.582

KCV81132.1

0.543

KCV81055.1

0.541

KCV81128.1

0.510

Your Current Organism:

Actibacterium atlanticum

NCBI taxonomy Id: 1461693
Other names: A. atlanticum, Actibacterium atlanticum Li et al. 2015, Actibacterium sp. 22II-S11-z10, LMG 27158, LMG:27158, MCCC 1A09298, strain 22II-S11-z10

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCV81046.1	KCV81055.1	ATO10_13774	ATO10_13819	Conjugal transfer protein TrbG/VirB9/CagX; COG3504 Type IV secretory pathway, VirB9 components.	Hypothetical protein.	0.870
KCV81046.1	KCV81105.1	ATO10_13774	ATO10_14069	Conjugal transfer protein TrbG/VirB9/CagX; COG3504 Type IV secretory pathway, VirB9 components.	COG4227 Antirestriction protein.	0.582
KCV81046.1	KCV81107.1	ATO10_13774	ATO10_14079	Conjugal transfer protein TrbG/VirB9/CagX; COG3504 Type IV secretory pathway, VirB9 components.	parB-like partition protein; COG1475 Predicted transcriptional regulators.	0.424
KCV81046.1	KCV81123.1	ATO10_13774	ATO10_14159	Conjugal transfer protein TrbG/VirB9/CagX; COG3504 Type IV secretory pathway, VirB9 components.	Putative methylase/helicase.	0.533
KCV81046.1	KCV81128.1	ATO10_13774	ATO10_14184	Conjugal transfer protein TrbG/VirB9/CagX; COG3504 Type IV secretory pathway, VirB9 components.	Hypothetical protein; RC175.	0.647
KCV81046.1	KCV81132.1	ATO10_13774	ATO10_14204	Conjugal transfer protein TrbG/VirB9/CagX; COG3504 Type IV secretory pathway, VirB9 components.	Hypothetical protein; RC172; COG3505 Type IV secretory pathway, VirD4 components.	0.897
KCV81055.1	KCV81046.1	ATO10_13819	ATO10_13774	Hypothetical protein.	Conjugal transfer protein TrbG/VirB9/CagX; COG3504 Type IV secretory pathway, VirB9 components.	0.870
KCV81055.1	KCV81105.1	ATO10_13819	ATO10_14069	Hypothetical protein.	COG4227 Antirestriction protein.	0.541
KCV81055.1	KCV81106.1	ATO10_13819	ATO10_14074	Hypothetical protein.	Hypothetical protein.	0.740
KCV81055.1	KCV81107.1	ATO10_13819	ATO10_14079	Hypothetical protein.	parB-like partition protein; COG1475 Predicted transcriptional regulators.	0.768
KCV81055.1	KCV81123.1	ATO10_13819	ATO10_14159	Hypothetical protein.	Putative methylase/helicase.	0.756
KCV81055.1	KCV81128.1	ATO10_13819	ATO10_14184	Hypothetical protein.	Hypothetical protein; RC175.	0.726
KCV81055.1	KCV81132.1	ATO10_13819	ATO10_14204	Hypothetical protein.	Hypothetical protein; RC172; COG3505 Type IV secretory pathway, VirD4 components.	0.764
KCV81102.1	KCV81103.1	ATO10_14054	ATO10_14059	Hypothetical protein.	Hypothetical protein.	0.999
KCV81102.1	KCV81105.1	ATO10_14054	ATO10_14069	Hypothetical protein.	COG4227 Antirestriction protein.	0.730
KCV81102.1	KCV81106.1	ATO10_14054	ATO10_14074	Hypothetical protein.	Hypothetical protein.	0.738
KCV81102.1	KCV81107.1	ATO10_14054	ATO10_14079	Hypothetical protein.	parB-like partition protein; COG1475 Predicted transcriptional regulators.	0.659
KCV81103.1	KCV81102.1	ATO10_14059	ATO10_14054	Hypothetical protein.	Hypothetical protein.	0.999
KCV81103.1	KCV81105.1	ATO10_14059	ATO10_14069	Hypothetical protein.	COG4227 Antirestriction protein.	0.713
KCV81103.1	KCV81106.1	ATO10_14059	ATO10_14074	Hypothetical protein.	Hypothetical protein.	0.698

page 1 of 4

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015628

Protein secretion by the type II secretion system

3 of 14

1.7

0.97

0.0110

GO:0009306

Protein secretion

4 of 33

1.45

0.89

0.0110

GO:0009297

Pilus assembly

2 of 7

1.82

0.78

0.0320

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

11 of 759

0.53

0.45

0.00020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4090

Bacterial secretion system, and Pilus organization

11 of 43

1.77

4.77

6.48e-17

CL:4091

Bacterial secretion system, and Pilus organization

10 of 36

1.81

4.7

1.74e-15

CL:4145

Pilus assembly, and Bacterial general secretion pathway protein G-type pilin

5 of 7

2.22

3.63

3.40e-08

CL:4095

Type II/IV secretion system protein, and GspF/PilC family

4 of 15

1.79

1.95

5.11e-05

CL:4112

Mixed, incl. Bacterial general secretion pathway protein G-type pilin, and Type II/IV secretion system protein

2 of 6

1.89

0.82

0.0266

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03070

Bacterial secretion system

8 of 55

1.53

2.66

1.24e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015627

Type II protein secretion system complex

5 of 8

2.16

3.31

1.42e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05157

Type II secretion system (T2SS), protein E, N-terminal domain

3 of 5

2.14

1.53

0.0012

PF00437

Type II/IV secretion system protein

2 of 5

1.97

0.73

0.0420

PF07963

Prokaryotic N-terminal methylation motif

3 of 25

1.44

0.7

0.0330

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045584

Pilin-like

6 of 24

1.76

2.56

6.28e-07

IPR001482

Type II/IV secretion system protein

4 of 11

1.93

1.91

0.00011

IPR037257

Type II secretion system protein GspE, N-terminal superfamily

3 of 5

2.14

1.56

0.0010

IPR007831

Type II secretion system protein GspE, N-terminal

3 of 5

2.14

1.56

0.0010

IPR000983

Bacterial general secretion pathway protein G-type pilin

3 of 5

2.14

1.56

0.0010

(more ...)

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