SER45692.1 protein (Salisediminibacterium haloalkalitolerans)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

SER45692.1

Phytoene dehydrogenase-related protein. (440 aa)

Predicted Functional Partners:

hemE

0.934

hemH

0.892

SES36864.1

0.795

SES27466.1

0.750

SER45242.1

0.742

SER45283.1

0.741

SER45367.1

0.737

SER45317.1

0.735

SER90667.1

0.732

SER74088.1

0.718

Your Current Organism:

Salisediminibacterium haloalkalitolerans

NCBI taxonomy Id: 1464123
Other names: CGMCC 1.12818, KCTC 33414, S. haloalkalitolerans, Salisediminibacterium haloalkalitolerans Sultanpuram et al. 2015, Salisediminibacterium sp. 10nlg, strain 10nlg

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SER45242.1	SER45283.1	SAMN05444126_101142	SAMN05444126_101143	Phytoene desaturase.	Phytoene synthase.	0.936
SER45242.1	SER45692.1	SAMN05444126_101142	SAMN05444126_101154	Phytoene desaturase.	Phytoene dehydrogenase-related protein.	0.742
SER45242.1	SER90667.1	SAMN05444126_101142	SAMN05444126_10889	Phytoene desaturase.	Monoamine oxidase.	0.454
SER45242.1	SES36864.1	SAMN05444126_101142	SAMN05444126_1466	Phytoene desaturase.	C-3',4' desaturase CrtD.	0.712
SER45283.1	SER45242.1	SAMN05444126_101143	SAMN05444126_101142	Phytoene synthase.	Phytoene desaturase.	0.936
SER45283.1	SER45317.1	SAMN05444126_101143	SAMN05444126_101144	Phytoene synthase.	Phytoene desaturase.	0.985
SER45283.1	SER45367.1	SAMN05444126_101143	SAMN05444126_101145	Phytoene synthase.	Phytoene desaturase.	0.988
SER45283.1	SER45692.1	SAMN05444126_101143	SAMN05444126_101154	Phytoene synthase.	Phytoene dehydrogenase-related protein.	0.741
SER45283.1	SER74088.1	SAMN05444126_101143	SAMN05444126_10525	Phytoene synthase.	Acetaldehyde dehydrogenase / alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.716
SER45283.1	SER90667.1	SAMN05444126_101143	SAMN05444126_10889	Phytoene synthase.	Monoamine oxidase.	0.766
SER45283.1	SES27466.1	SAMN05444126_101143	SAMN05444126_1268	Phytoene synthase.	Diapolycopene oxygenase.	0.938
SER45283.1	SES36864.1	SAMN05444126_101143	SAMN05444126_1466	Phytoene synthase.	C-3',4' desaturase CrtD.	0.897
SER45317.1	SER45283.1	SAMN05444126_101144	SAMN05444126_101143	Phytoene desaturase.	Phytoene synthase.	0.985
SER45317.1	SER45367.1	SAMN05444126_101144	SAMN05444126_101145	Phytoene desaturase.	Phytoene desaturase.	0.822
SER45317.1	SER45692.1	SAMN05444126_101144	SAMN05444126_101154	Phytoene desaturase.	Phytoene dehydrogenase-related protein.	0.735
SER45317.1	SER90667.1	SAMN05444126_101144	SAMN05444126_10889	Phytoene desaturase.	Monoamine oxidase.	0.449
SER45317.1	SES36864.1	SAMN05444126_101144	SAMN05444126_1466	Phytoene desaturase.	C-3',4' desaturase CrtD.	0.697
SER45367.1	SER45283.1	SAMN05444126_101145	SAMN05444126_101143	Phytoene desaturase.	Phytoene synthase.	0.988
SER45367.1	SER45317.1	SAMN05444126_101145	SAMN05444126_101144	Phytoene desaturase.	Phytoene desaturase.	0.822
SER45367.1	SER45692.1	SAMN05444126_101145	SAMN05444126_101154	Phytoene desaturase.	Phytoene dehydrogenase-related protein.	0.737

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.929

expected number of edges:

15

PPI enrichment p-value:

3.88e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033014

Tetrapyrrole biosynthetic process

11 of 21

2.07

6.86

2.33e-19

GO:0009236

Cobalamin biosynthetic process

10 of 16

2.15

6.83

7.88e-18

GO:0032259

Methylation

6 of 59

1.36

1.69

4.61e-06

GO:0006541

Glutamine metabolic process

2 of 11

1.61

0.67

0.0474

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008168

Methyltransferase activity

6 of 57

1.38

1.51

4.80e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35864536

(2022) Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants.

8 of 10

2.26

6.17

1.52e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3483

Cobalamin metabolic process

10 of 10

2.35

8.09

4.45e-19

CL:3480

Tetrapyrrole biosynthetic process, and ABC transporter, permease protein, BtuC-like

11 of 31

1.9

5.72

2.08e-18

CL:3485

Tetrapyrrole methylase

5 of 5

2.35

3.97

1.14e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00860

Porphyrin and chlorophyll metabolism

11 of 44

1.75

4.72

2.22e-17

map01100

Metabolic pathways

11 of 814

0.48

0.41

0.00026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0169

Cobalamin biosynthesis

4 of 6

2.18

2.56

8.09e-06

KW-0489

Methyltransferase

5 of 48

1.37

1.4

0.00014

KW-0949

S-adenosyl-L-methionine

3 of 34

1.3

0.68

0.0290

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00590

Tetrapyrrole (Corrin/Porphyrin) Methylases

5 of 6

2.27

3.47

1.09e-07

PF07685

CobB/CobQ-like glutamine amidotransferase domain

2 of 3

2.18

0.78

0.0363

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035996

Tetrapyrrole methylase superfamily

5 of 6

2.27

3.28

2.81e-07

IPR014777

Tetrapyrrole methylase, subdomain 1

5 of 6

2.27

3.28

2.81e-07

IPR014776

Tetrapyrrole methylase, subdomain 2

5 of 6

2.27

3.28

2.81e-07

IPR000878

Tetrapyrrole methylase

5 of 6

2.27

3.28

2.81e-07

IPR011698

CobB/CobQ-like glutamine amidotransferase

2 of 2

2.35

0.9

0.0225

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