node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SER43897.1 | SER97391.1 | SAMN05444126_101103 | SAMN05444126_11053 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetolactate synthase, large subunit. | 0.784 |
SER43897.1 | SER97427.1 | SAMN05444126_101103 | SAMN05444126_11054 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Acetolactate synthase, small subunit. | 0.862 |
SER43897.1 | SES30006.1 | SAMN05444126_101103 | SAMN05444126_12916 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Homoserine dehydrogenase. | 0.968 |
SER43897.1 | ilvC | SAMN05444126_101103 | SAMN05444126_11055 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.710 |
SER43897.1 | leuA | SAMN05444126_101103 | SAMN05444126_11056 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.731 |
SER43897.1 | leuB | SAMN05444126_101103 | SAMN05444126_11057 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.677 |
SER43897.1 | leuC | SAMN05444126_101103 | SAMN05444126_11058 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.766 |
SER43897.1 | leuD | SAMN05444126_101103 | SAMN05444126_11059 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.634 |
SER97391.1 | SER43897.1 | SAMN05444126_11053 | SAMN05444126_101103 | Acetolactate synthase, large subunit. | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.784 |
SER97391.1 | SER97427.1 | SAMN05444126_11053 | SAMN05444126_11054 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
SER97391.1 | SES30006.1 | SAMN05444126_11053 | SAMN05444126_12916 | Acetolactate synthase, large subunit. | Homoserine dehydrogenase. | 0.996 |
SER97391.1 | ilvC | SAMN05444126_11053 | SAMN05444126_11055 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.997 |
SER97391.1 | ilvD | SAMN05444126_11053 | SAMN05444126_12244 | Acetolactate synthase, large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.990 |
SER97391.1 | leuA | SAMN05444126_11053 | SAMN05444126_11056 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.983 |
SER97391.1 | leuB | SAMN05444126_11053 | SAMN05444126_11057 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.982 |
SER97391.1 | leuC | SAMN05444126_11053 | SAMN05444126_11058 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.962 |
SER97391.1 | leuD | SAMN05444126_11053 | SAMN05444126_11059 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.974 |
SER97427.1 | SER43897.1 | SAMN05444126_11054 | SAMN05444126_101103 | Acetolactate synthase, small subunit. | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.862 |
SER97427.1 | SER97391.1 | SAMN05444126_11054 | SAMN05444126_11053 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SER97427.1 | SES30006.1 | SAMN05444126_11054 | SAMN05444126_12916 | Acetolactate synthase, small subunit. | Homoserine dehydrogenase. | 0.791 |