node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SER71657.1 | SES21474.1 | SAMN05444126_104139 | SAMN05444126_1218 | Hydroxyacylglutathione hydrolase. | Hydroxyacylglutathione hydrolase. | 0.907 |
SER71657.1 | SES22869.1 | SAMN05444126_104139 | SAMN05444126_12215 | Hydroxyacylglutathione hydrolase. | Hypothetical protein. | 0.429 |
SER71657.1 | guaA | SAMN05444126_104139 | SAMN05444126_11762 | Hydroxyacylglutathione hydrolase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.510 |
SER71657.1 | pheT | SAMN05444126_104139 | SAMN05444126_11226 | Hydroxyacylglutathione hydrolase. | phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.503 |
SES21474.1 | SER71657.1 | SAMN05444126_1218 | SAMN05444126_104139 | Hydroxyacylglutathione hydrolase. | Hydroxyacylglutathione hydrolase. | 0.907 |
SES21474.1 | SES22869.1 | SAMN05444126_1218 | SAMN05444126_12215 | Hydroxyacylglutathione hydrolase. | Hypothetical protein. | 0.417 |
SES21474.1 | guaA | SAMN05444126_1218 | SAMN05444126_11762 | Hydroxyacylglutathione hydrolase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.510 |
SES21474.1 | pheT | SAMN05444126_1218 | SAMN05444126_11226 | Hydroxyacylglutathione hydrolase. | phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.503 |
SES22782.1 | SES22824.1 | SAMN05444126_12211 | SAMN05444126_12213 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant). | 0.712 |
SES22782.1 | SES22847.1 | SAMN05444126_12211 | SAMN05444126_12214 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | 0.780 |
SES22782.1 | SES22869.1 | SAMN05444126_12211 | SAMN05444126_12215 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein. | 0.555 |
SES22782.1 | SES22889.1 | SAMN05444126_12211 | SAMN05444126_12216 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Uncharacterized conserved protein YecE, DUF72 family. | 0.439 |
SES22782.1 | guaA | SAMN05444126_12211 | SAMN05444126_11762 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.433 |
SES22782.1 | thyA | SAMN05444126_12211 | SAMN05444126_12212 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
SES22824.1 | SES22782.1 | SAMN05444126_12213 | SAMN05444126_12211 | HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.712 |
SES22824.1 | SES22847.1 | SAMN05444126_12213 | SAMN05444126_12214 | HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant). | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | 0.724 |
SES22824.1 | SES22869.1 | SAMN05444126_12213 | SAMN05444126_12215 | HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant). | Hypothetical protein. | 0.591 |
SES22824.1 | SES22889.1 | SAMN05444126_12213 | SAMN05444126_12216 | HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant). | Uncharacterized conserved protein YecE, DUF72 family. | 0.458 |
SES22824.1 | thyA | SAMN05444126_12213 | SAMN05444126_12212 | HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant). | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.713 |
SES22847.1 | SES22782.1 | SAMN05444126_12214 | SAMN05444126_12211 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.780 |