STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.998
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.995
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.992
ANJ06521.1
Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the shikimate dehydrogenase family.
  
 0.985
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
 
 0.984
ANJ09763.1
Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.980
ANJ06989.1
Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.974
ANJ09074.1
Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.974
ANJ09762.1
Anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.960
aroH
Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.959
Your Current Organism:
Streptomyces parvulus
NCBI taxonomy Id: 146923
Other names: ATCC 12434, ATCC 19796, BCRC 12046, CBS 418.59, CBS 548.68, CCRC 12046, CCRC:12046, DSM 40048, HUT 6081, ICMP 156, IFO 13193, IMET 41380, ISP 5048, JCM 4068, JCM 4601, LMG 19312, LMG:19312, NBRC 13193, NCIMB 11240, NRRL-ISP 5048, RIA 507, S. parvulus, Streptomyces parvullus, Streptomyces sp. RL01, Streptomyces sp. USC012, Streptomyces sp. USC013, UNIQEM 182
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