STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRM22_005681Bromo domain-containing protein. (1548 aa)    
Predicted Functional Partners:
CRM22_004965
PCI domain-containing protein.
   
 0.879
CRM22_002598
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 
 0.871
CRM22_004765
PCI domain-containing protein.
   
 0.867
CRM22_004388
Uncharacterized protein.
   
 
 0.866
CRM22_006913
PCI domain-containing protein.
   
 0.865
CRM22_009187
PCI domain-containing protein.
   
 0.860
CRM22_005002
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
   
 0.855
CRM22_001998
DAO domain-containing protein.
  
 0.853
CRM22_001521
Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
  
 0.853
CRM22_006992
Proteasome subunit alpha type.
   
 0.850
Your Current Organism:
Opisthorchis felineus
NCBI taxonomy Id: 147828
Other names: O. felineus, cat liver fluke
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.