STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mecANegative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. (219 aa)    
Predicted Functional Partners:
AKP45491.1
ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family.
    
 
 0.824
clpB
ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
    
 
 0.758
AKP46643.1
ClpB protein; Belongs to the ClpA/ClpB family.
    
 
 0.758
AKP46414.1
Competence protein CoiA.
 
     0.720
AKP48157.1
Hypothetical protein; Belongs to the UPF0354 family.
  
     0.691
AKP46421.1
YjbH-likeGTP pyrophosphokinase domain.
  
  
 0.686
AKP46331.1
Competence transcription factor.
  
   
 0.684
AKP48211.1
8-oxo-dGTPase Bsu YtkD 8-oxo-GTPase Bsu YtkD; Belongs to the Nudix hydrolase family.
  
     0.670
AKP45436.1
DNA replication initiation control protein YabA; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
     0.651
ezrA
Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
     0.635
Your Current Organism:
Bacillus smithii
NCBI taxonomy Id: 1479
Other names: B. smithii, CCUG 27413, CIP 103790, DSM 4216, IFO 15311, JCM 9076, LMG 12526, LMG:12526, NBRC 15311, NRRL NRS-173
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