node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKP45491.1 | AKP47310.1 | BSM4216_0108 | BSM4216_2058 | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | Translocation-enhancing protein TepA. | 0.830 |
AKP45491.1 | clpP | BSM4216_0108 | BSM4216_0576 | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.880 |
AKP45491.1 | dnaJ | BSM4216_0108 | BSM4216_2630 | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.730 |
AKP45491.1 | dnaK | BSM4216_0108 | BSM4216_2631 | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.917 |
AKP45491.1 | groL | BSM4216_0108 | BSM4216_3465 | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.589 |
AKP45491.1 | grpE | BSM4216_0108 | BSM4216_2632 | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.723 |
AKP45491.1 | hrcA | BSM4216_0108 | BSM4216_2633 | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.537 |
AKP46643.1 | AKP47310.1 | BSM4216_1362 | BSM4216_2058 | ClpB protein; Belongs to the ClpA/ClpB family. | Translocation-enhancing protein TepA. | 0.830 |
AKP46643.1 | clpP | BSM4216_1362 | BSM4216_0576 | ClpB protein; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.880 |
AKP46643.1 | dnaJ | BSM4216_1362 | BSM4216_2630 | ClpB protein; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.730 |
AKP46643.1 | dnaK | BSM4216_1362 | BSM4216_2631 | ClpB protein; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.915 |
AKP46643.1 | groL | BSM4216_1362 | BSM4216_3465 | ClpB protein; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.589 |
AKP46643.1 | grpE | BSM4216_1362 | BSM4216_2632 | ClpB protein; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.722 |
AKP46643.1 | hrcA | BSM4216_1362 | BSM4216_2633 | ClpB protein; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.536 |
AKP47310.1 | AKP45491.1 | BSM4216_2058 | BSM4216_0108 | Translocation-enhancing protein TepA. | ATP-binding subunit ClpC Negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | 0.830 |
AKP47310.1 | AKP46643.1 | BSM4216_2058 | BSM4216_1362 | Translocation-enhancing protein TepA. | ClpB protein; Belongs to the ClpA/ClpB family. | 0.830 |
AKP47310.1 | dnaJ | BSM4216_2058 | BSM4216_2630 | Translocation-enhancing protein TepA. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.497 |
AKP47310.1 | dnaK | BSM4216_2058 | BSM4216_2631 | Translocation-enhancing protein TepA. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.666 |
AKP47310.1 | groL | BSM4216_2058 | BSM4216_3465 | Translocation-enhancing protein TepA. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.615 |
AKP47310.1 | grpE | BSM4216_2058 | BSM4216_2632 | Translocation-enhancing protein TepA. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.631 |