Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ureDHypothetical protein; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. (233 aa)    
Predicted Functional Partners:
OAR04401.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease gamma subunit family.
 
 
 0.998
ureF
Hypothetical protein; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
 
 
 0.989
ureC
Urease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.983
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
 
 
 0.953
ureE
Hypothetical protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
 
   
 0.943
OAR04399.1
Urea ABC transporter ATP-binding protein UrtD; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.614
OAR04380.1
Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.563
OAR04400.1
Urea ABC transporter ATP-binding subunit UrtE; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.541
OAR05494.1
Hydantoin utilization protein A; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.499
OAR04398.1
Urea ABC transporter permease subunit UrtC; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family.
     
 0.493
Your Current Organism:
Hydrogenibacillus schlegelii
NCBI taxonomy Id: 1484
Other names: ATCC 43741, Bacillus schlegelii, CCUG 26017, CIP 106933, DSM 2000, H. schlegelii, LMG 7133, LMG:7133, strain MA 48
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