STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topBDNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (727 aa)    
Predicted Functional Partners:
recQ-2
ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.889
ALR90249.1
DNA replication protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.879
ALP88851.1
DNA replication protein DnaC; Acts to load the DnaB helicase onto the initiation site during DNA replication; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DnaA family.
  
  
 0.875
ALP91860.1
AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.873
copZ
Heavy metal transport/detoxification protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.819
recQ
ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.812
ALP91551.1
RNA polymerase subunit sigma-70; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
   
 
 0.784
nifJ
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.766
nifJ-2
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.766
nifJ-3
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.766
Your Current Organism:
Clostridium butyricum
NCBI taxonomy Id: 1492
Other names: ATCC 19398, Amylobacter navicula, Bacillus amylobacter, Bacillus butyricus, Bacillus navicula, Bacterium navicula, C. butyricum, CCUG 4217, CIP 103309, Clostridium kainantoi, Clostridium naviculum, Clostridium pseudotetanicum, DSM 10702, HAMBI 482, IAM 14194, IFO 13949, Metallacter amylobacter, NBRC 13949, NCCB 89156, NCIB 7423, NCIMB 7423, NCTC 7423, VPI 3266
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