AMH94321.1 protein (methanogenic archaeon ISO4H5)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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Score

AMH94321.1

HTH domain-containing protein. (230 aa)

Predicted Functional Partners:

AMH94322.1

0.961

AMH94324.1

0.909

AMH94323.1

0.905

carS

0.654

AMH94325.1

0.651

AMH94503.1

0.632

AMH93781.1

0.625

AMH94159.1

0.592

AMH94187.1

0.587

rpl29

0.576

Your Current Organism:

methanogenic archaeon ISO4H5

NCBI taxonomy Id: 1495144
Other names: Thermoplasmatales archaeon enrichment culture clone ISO4-H5, m. archaeon ISO4-H5, methanogenic archaeon ISO4-H5, methanogenic archaeon mixed culture ISO4-H5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH93781.1	AMH94321.1	AR505_0059	AR505_0600	Radical SAM domain protein.	HTH domain-containing protein.	0.625
AMH93781.1	AMH94503.1	AR505_0059	AR505_0782	Radical SAM domain protein.	Transmembrane protein.	0.692
AMH93781.1	carS	AR505_0059	AR505_1616	Radical SAM domain protein.	CDP-diglyceride synthetase CdsA; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.	0.550
AMH93781.1	rpl29	AR505_0059	AR505_0225	Radical SAM domain protein.	Ribosomal protein L29P Rpl29p; Belongs to the universal ribosomal protein uL29 family.	0.513
AMH94159.1	AMH94187.1	AR505_0438	AR505_0466	Archaeosine tRNA-ribosyltransferase TgtA1.	S-adenosylmethionine synthetase MetK.	0.435
AMH94159.1	AMH94321.1	AR505_0438	AR505_0600	Archaeosine tRNA-ribosyltransferase TgtA1.	HTH domain-containing protein.	0.592
AMH94159.1	carS	AR505_0438	AR505_1616	Archaeosine tRNA-ribosyltransferase TgtA1.	CDP-diglyceride synthetase CdsA; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.	0.526
AMH94159.1	rpl29	AR505_0438	AR505_0225	Archaeosine tRNA-ribosyltransferase TgtA1.	Ribosomal protein L29P Rpl29p; Belongs to the universal ribosomal protein uL29 family.	0.570
AMH94187.1	AMH94159.1	AR505_0466	AR505_0438	S-adenosylmethionine synthetase MetK.	Archaeosine tRNA-ribosyltransferase TgtA1.	0.435
AMH94187.1	AMH94321.1	AR505_0466	AR505_0600	S-adenosylmethionine synthetase MetK.	HTH domain-containing protein.	0.587
AMH94187.1	carS	AR505_0466	AR505_1616	S-adenosylmethionine synthetase MetK.	CDP-diglyceride synthetase CdsA; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.	0.425
AMH94321.1	AMH93781.1	AR505_0600	AR505_0059	HTH domain-containing protein.	Radical SAM domain protein.	0.625
AMH94321.1	AMH94159.1	AR505_0600	AR505_0438	HTH domain-containing protein.	Archaeosine tRNA-ribosyltransferase TgtA1.	0.592
AMH94321.1	AMH94187.1	AR505_0600	AR505_0466	HTH domain-containing protein.	S-adenosylmethionine synthetase MetK.	0.587
AMH94321.1	AMH94322.1	AR505_0600	AR505_0601	HTH domain-containing protein.	hydroxymethylglutaryl-CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family.	0.961
AMH94321.1	AMH94323.1	AR505_0600	AR505_0602	HTH domain-containing protein.	acetyl-CoA acetyltransferase.	0.905
AMH94321.1	AMH94324.1	AR505_0600	AR505_0603	HTH domain-containing protein.	DNA-binding protein.	0.909
AMH94321.1	AMH94325.1	AR505_0600	AR505_0604	HTH domain-containing protein.	Phosphoglycolate phosphatase.	0.651
AMH94321.1	AMH94503.1	AR505_0600	AR505_0782	HTH domain-containing protein.	Transmembrane protein.	0.632
AMH94321.1	carS	AR505_0600	AR505_1616	HTH domain-containing protein.	CDP-diglyceride synthetase CdsA; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.	0.654

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016226

Iron-sulfur cluster assembly

7 of 17

2.48

6.2

2.29e-13

GO:0006790

Sulfur compound metabolic process

10 of 159

1.66

3.71

2.29e-13

GO:0006534

Cysteine metabolic process

3 of 27

1.91

1.41

0.0015

GO:0008152

Metabolic process

11 of 3487

0.36

0.28

0.0157

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031071

Cysteine desulfurase activity

3 of 8

2.44

1.89

0.00030

GO:0097163

Sulfur carrier activity

2 of 7

2.32

1.0

0.0145

GO:0030170

Pyridoxal phosphate binding

3 of 56

1.59

0.89

0.0145

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990229

Iron-sulfur cluster assembly complex

3 of 3

2.86

2.82

6.78e-06

GO:0005737

Cytoplasm

11 of 2117

0.58

0.51

3.93e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2971

Sulfur relay system, and Iron-sulfur cluster assembly

11 of 44

2.26

8.53

8.62e-22

CL:2973

Sulfur relay system, and Iron-sulfur cluster assembly

9 of 26

2.4

7.92

4.07e-18

CL:3005

Iron-sulfur cluster assembly complex, and Cysteine desulfurase activity

7 of 10

2.71

7.32

4.82e-15

CL:3009

Iron-sulfur cluster assembly complex, and NifU-like N terminal domain

5 of 5

2.86

5.32

1.12e-10

CL:2980

Sulfur carrier activity, and Cysteine desulfurase activity

2 of 6

2.39

1.07

0.0110

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00450

Selenocompound metabolism

5 of 25

2.16

3.58

3.23e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990221

L-cysteine desulfurase complex

4 of 6

2.69

3.63

1.57e-07

GOCC:1990330

IscS-IscU complex

2 of 2

2.86

1.49

0.0020

GOCC:0005622

Intracellular

10 of 2469

0.47

0.36

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0663

Pyridoxal phosphate

3 of 55

1.6

0.89

0.0144

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01592

NifU-like N terminal domain

2 of 2

2.86

1.11

0.0100

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