AMH94831.1 protein (methanogenic archaeon ISO4H5)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

AMH94831.1

Hypothetical protein. (696 aa)

Predicted Functional Partners:

AMH94830.1

0.773

AMH94832.1

0.773

AMH94833.1

0.773

AMH94829.1

0.532

Your Current Organism:

methanogenic archaeon ISO4H5

NCBI taxonomy Id: 1495144
Other names: Thermoplasmatales archaeon enrichment culture clone ISO4-H5, m. archaeon ISO4-H5, methanogenic archaeon ISO4-H5, methanogenic archaeon mixed culture ISO4-H5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH94829.1	AMH94830.1	AR505_1111	AR505_1112	Hypothetical protein.	Hypothetical protein.	0.532
AMH94829.1	AMH94831.1	AR505_1111	AR505_1113	Hypothetical protein.	Hypothetical protein.	0.532
AMH94829.1	AMH94832.1	AR505_1111	AR505_1114	Hypothetical protein.	Hypothetical protein.	0.532
AMH94829.1	AMH94833.1	AR505_1111	AR505_1115	Hypothetical protein.	DEAD/DEAH box helicase domain-containing protein.	0.532
AMH94830.1	AMH94829.1	AR505_1112	AR505_1111	Hypothetical protein.	Hypothetical protein.	0.532
AMH94830.1	AMH94831.1	AR505_1112	AR505_1113	Hypothetical protein.	Hypothetical protein.	0.773
AMH94830.1	AMH94832.1	AR505_1112	AR505_1114	Hypothetical protein.	Hypothetical protein.	0.773
AMH94830.1	AMH94833.1	AR505_1112	AR505_1115	Hypothetical protein.	DEAD/DEAH box helicase domain-containing protein.	0.773
AMH94831.1	AMH94829.1	AR505_1113	AR505_1111	Hypothetical protein.	Hypothetical protein.	0.532
AMH94831.1	AMH94830.1	AR505_1113	AR505_1112	Hypothetical protein.	Hypothetical protein.	0.773
AMH94831.1	AMH94832.1	AR505_1113	AR505_1114	Hypothetical protein.	Hypothetical protein.	0.773
AMH94831.1	AMH94833.1	AR505_1113	AR505_1115	Hypothetical protein.	DEAD/DEAH box helicase domain-containing protein.	0.773
AMH94832.1	AMH94829.1	AR505_1114	AR505_1111	Hypothetical protein.	Hypothetical protein.	0.532
AMH94832.1	AMH94830.1	AR505_1114	AR505_1112	Hypothetical protein.	Hypothetical protein.	0.773
AMH94832.1	AMH94831.1	AR505_1114	AR505_1113	Hypothetical protein.	Hypothetical protein.	0.773
AMH94832.1	AMH94833.1	AR505_1114	AR505_1115	Hypothetical protein.	DEAD/DEAH box helicase domain-containing protein.	0.963
AMH94833.1	AMH94829.1	AR505_1115	AR505_1111	DEAD/DEAH box helicase domain-containing protein.	Hypothetical protein.	0.532
AMH94833.1	AMH94830.1	AR505_1115	AR505_1112	DEAD/DEAH box helicase domain-containing protein.	Hypothetical protein.	0.773
AMH94833.1	AMH94831.1	AR505_1115	AR505_1113	DEAD/DEAH box helicase domain-containing protein.	Hypothetical protein.	0.773
AMH94833.1	AMH94832.1	AR505_1115	AR505_1114	DEAD/DEAH box helicase domain-containing protein.	Hypothetical protein.	0.963

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

67

PPI enrichment p-value:

0.224

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 37

1.53

2.07

1.60e-06

GO:0007165

Signal transduction

10 of 154

1.13

1.48

3.08e-08

GO:0050896

Response to stimulus

11 of 262

0.94

1.09

3.08e-08

GO:0050794

Regulation of cellular process

11 of 292

0.89

1.01

4.04e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

6 of 38

1.51

1.96

3.90e-06

GO:0000155

Phosphorelay sensor kinase activity

5 of 37

1.45

1.58

5.90e-05

GO:0016772

Transferase activity, transferring phosphorus-containing groups

10 of 171

1.08

1.38

3.95e-08

GO:0003824

Catalytic activity

11 of 1162

0.29

0.24

0.0289

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 399

0.72

0.67

9.67e-06

GO:0016021

Integral component of membrane

11 of 504

0.66

0.61

7.12e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2413

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Putative diguanylate phosphodiesterase

9 of 26

1.86

4.62

4.79e-14

CL:2411

PAS-associated, C-terminal, and Histidine Phosphotransfer domain

10 of 35

1.77

4.37

1.51e-14

CL:2415

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Membrane-associated sensor domain

7 of 19

1.88

3.92

8.96e-11

CL:2400

Signaling

11 of 70

1.51

3.23

1.51e-14

CL:2420

Mixed, incl. PAS fold-3, and Chemotaxis response regulator CheV

4 of 6

2.14

2.86

1.47e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 275

0.92

1.07

1.00e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016020

Membrane

11 of 436

0.72

0.69

3.38e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

7 of 91

1.2

1.37

1.11e-05

KW-0175

Coiled coil

8 of 173

0.98

1.01

1.61e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13493

Domain of unknown function (DUF4118)

2 of 2

2.32

0.75

0.0426

PF10114

Sensory domain found in PocR

2 of 3

2.14

0.74

0.0426

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

10 of 44

1.67

3.75

2.22e-13

IPR001610

PAC motif

7 of 19

1.88

3.73

4.27e-10

IPR003594

Histidine kinase/HSP90-like ATPase

10 of 46

1.65

3.68

2.22e-13

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

10 of 47

1.64

3.64

2.22e-13

IPR013656

PAS fold-4

7 of 21

1.84

3.58

5.96e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

10 of 46

1.65

3.81

2.83e-14

SM00388

His Kinase A (phosphoacceptor) domain

8 of 35

1.68

3.36

4.89e-11

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

8 of 35

1.68

3.36

4.89e-11

SM00091

PAS domain

8 of 39

1.63

3.2

5.28e-11

SM00073

Histidine Phosphotransfer domain

3 of 9

1.84

1.73

0.00023

(more ...)

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