DO97_05705 protein (Neosynechococcus sphagnicola)

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Predicted Interactions

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DO97_05705

Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily. (243 aa)

Predicted Functional Partners:

DO97_01955

0.921

DO97_15510

0.860

DO97_01635

0.851

DO97_07035

0.791

DO97_17575

0.791

DO97_07040

0.767

DO97_17570

0.767

DO97_07000

0.751

DO97_05095

0.723

cysA

0.720

Your Current Organism:

Neosynechococcus sphagnicola

NCBI taxonomy Id: 1497020
Other names: Chroococcales cyanobacterium sy1, N. sphagnicola sy1, Neosynechococcus sphagnicola sy1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DO97_01635	DO97_05705	DO97_01635	DO97_05705	3-mercaptopyruvate sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	0.851
DO97_01955	DO97_05705	DO97_01955	DO97_05705	uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	0.921
DO97_01955	DO97_07000	DO97_01955	DO97_07000	uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.429
DO97_05095	DO97_05705	DO97_05095	DO97_05705	Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	0.723
DO97_05095	DO97_07000	DO97_05095	DO97_07000	Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
DO97_05705	DO97_01635	DO97_05705	DO97_01635	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	3-mercaptopyruvate sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.851
DO97_05705	DO97_01955	DO97_05705	DO97_01955	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.921
DO97_05705	DO97_05095	DO97_05705	DO97_05095	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.723
DO97_05705	DO97_07000	DO97_05705	DO97_07000	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.751
DO97_05705	DO97_07035	DO97_05705	DO97_07035	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Sulfate transporter; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	0.791
DO97_05705	DO97_07040	DO97_05705	DO97_07040	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Sulfate transport system permease CysW; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.767
DO97_05705	DO97_15510	DO97_05705	DO97_15510	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Sulfate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.860
DO97_05705	DO97_17570	DO97_05705	DO97_17570	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Sulfate transport system permease CysW; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.767
DO97_05705	DO97_17575	DO97_05705	DO97_17575	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Sulfate transporter; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	0.791
DO97_05705	cysA	DO97_05705	DO97_14310	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	Sulfate ABC transporter ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.	0.720
DO97_07000	DO97_01955	DO97_07000	DO97_01955	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.429
DO97_07000	DO97_05095	DO97_07000	DO97_05095	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
DO97_07000	DO97_05705	DO97_07000	DO97_05705	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	0.751
DO97_07035	DO97_05705	DO97_07035	DO97_05705	Sulfate transporter; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Phosphoadenosine phosphosulfate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PAPS reductase family. CysH subfamily.	0.791
DO97_07035	DO97_07040	DO97_07035	DO97_07040	Sulfate transporter; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Sulfate transport system permease CysW; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

18

PPI enrichment p-value:

4.94e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035556

Intracellular signal transduction

6 of 251

1.49

1.72

2.45e-05

GO:0007165

Signal transduction

7 of 427

1.32

1.5

2.45e-05

GO:0010737

Protein kinase A signaling

2 of 4

2.81

1.38

0.0031

GO:0006796

Phosphate-containing compound metabolic process

6 of 765

1.0

0.77

0.0032

GO:0048519

Negative regulation of biological process

5 of 541

1.07

0.73

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004690

Cyclic nucleotide-dependent protein kinase activity

4 of 5

3.01

4.05

3.74e-08

GO:0004679

AMP-activated protein kinase activity

3 of 3

3.11

2.91

5.24e-06

GO:0004691

cAMP-dependent protein kinase activity

3 of 4

2.98

2.86

6.11e-06

GO:0019003

GDP binding

2 of 3

2.93

1.48

0.0021

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 544

1.07

0.79

0.0045

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005952

cAMP-dependent protein kinase complex

2 of 4

2.81

1.21

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3280

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

5 of 16

2.6

4.43

3.23e-09

CL:3208

Mixed, incl. Peptidyl-serine phosphorylation, and Aquaporin-mediated transport

6 of 52

2.17

3.99

3.23e-09

CL:3282

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

4 of 11

2.67

3.66

1.31e-07

CL:3285

G protein activity, and Cyclic nucleotide-dependent protein kinase activity

3 of 5

2.89

2.8

7.61e-06

CL:2922

Protein kinase domain, and GTPase regulator activity

7 of 196

1.66

2.76

2.32e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

4 of 131

1.59

1.5

0.00035

map04138

Autophagy - yeast

3 of 150

1.41

0.84

0.0135

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9634597

GPER1 signaling

3 of 4

2.98

2.88

5.70e-06

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

3 of 4

2.98

2.88

5.70e-06

MAP-164378

PKA activation in glucagon signalling

3 of 4

2.98

2.88

5.70e-06

MAP-163615

PKA activation

3 of 4

2.98

2.88

5.70e-06

MAP-163359

Glucagon signaling in metabolic regulation

3 of 4

2.98

2.88

5.70e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 5

2.89

2.59

1.86e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020849

Small GTPase, Ras-type

2 of 4

2.81

0.91

0.0225

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00173

Ras subfamily of RAS small GTPases

2 of 3

2.93

1.53

0.0017

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