ER57_06885 protein (Smithella sp. SCADC) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

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[Homology]

Score

ER57_06885

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)

Predicted Functional Partners:

ER57_06890

0.746

ER57_06895

0.746

ER57_06900

0.607

ER57_06905

0.519

Your Current Organism:

Smithella sp. SCADC

NCBI taxonomy Id: 1499107
Other names: S. sp. SCADC, Smithella sp. enrichment culture clone SCADC

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Browse interactions in tabular form:

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.958

expected number of edges:

12

PPI enrichment p-value:

1.24e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003700

DNA-binding transcription factor activity

11 of 178

1.49

3.08

4.99e-14

GO:0003677

DNA binding

11 of 423

1.11

1.57

1.84e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1740

0.5

0.42

0.00053

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8614

GntR, C-terminal

10 of 29

2.24

7.55

5.97e-19

CL:8612

GntR, C-terminal, and Protein of unknown function DUF112, transmembrane

11 of 55

2.0

6.41

3.69e-19

CL:8616

GntR, C-terminal

6 of 24

2.1

3.94

2.11e-09

CL:8644

GntR, C-terminal

3 of 10

2.18

1.76

0.00041

CL:8617

GntR, C-terminal

3 of 14

2.03

1.58

0.00080

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032993

protein-DNA complex

9 of 94

1.68

3.58

3.70e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0805

Transcription regulation

11 of 205

1.43

2.82

5.96e-14

KW-0238

DNA-binding

11 of 260

1.33

2.38

2.54e-13

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00392

Bacterial regulatory proteins, gntR family

4 of 5

2.6

3.24

7.88e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011711

GntR, C-terminal

11 of 37

2.17

7.73

1.16e-20

IPR008920

Transcription regulator FadR/GntR, C-terminal

11 of 37

2.17

7.73

1.16e-20

IPR000524

Transcription regulator HTH, GntR

11 of 41

2.13

7.48

1.16e-20

IPR036390

Winged helix DNA-binding domain superfamily

11 of 163

1.53

3.31

1.03e-14

IPR036388

Winged helix-like DNA-binding domain superfamily

11 of 214

1.41

2.72

1.51e-13

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00895

This entry represents the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding ...

11 of 37

2.17

8.04

8.09e-22

SM00345

Helix_turn_helix gluconate operon transcriptional repressor

7 of 36

1.99

4.38

2.16e-11

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node1	node2	node1 annotation	node2 annotation	score
ER57_06885	ER57_06890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
ER57_06885	ER57_06895	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.746
ER57_06885	ER57_06900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.607
ER57_06885	ER57_06905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.519
ER57_06890	ER57_06885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
ER57_06890	ER57_06895	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
ER57_06890	ER57_06900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
ER57_06890	ER57_06905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.536
ER57_06895	ER57_06885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
ER57_06895	ER57_06890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
ER57_06895	ER57_06900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
ER57_06895	ER57_06905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.536
ER57_06900	ER57_06885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.607
ER57_06900	ER57_06890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
ER57_06900	ER57_06895	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.628
ER57_06900	ER57_06905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.655
ER57_06905	ER57_06885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.519
ER57_06905	ER57_06890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.536
ER57_06905	ER57_06895	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.536
ER57_06905	ER57_06900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.655