STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EV05_1489Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (328 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.990
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.976
EV05_0940
Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.949
EV05_0387
Uroporphyrinogen-III methyltransferase; Alternative locus ID: PMIT0601_1784; Belongs to the precorrin methyltransferase family.
    
 0.933
EV05_1488
Nucleoside-diphosphate-sugar epimerase; Alternative locus ID: PMIT0601_0410.
       0.831
EV05_1175
Oxygen independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.802
EV05_0197
Ferredoxin-dependent glutamate synthase; Alternative locus ID: PMIT0601_1593.
    
 0.777
EV05_1487
Plastocyanin; Alternative locus ID: PMIT0601_0409.
       0.747
EV05_0830
Porphobilinogen synthase; Alternative locus ID: PMIT0601_1272; Belongs to the ALAD family.
 
 
 0.724
EV05_0751
Protoporphyrin IX Mg-chelatase subunit D; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
  
 
 0.677
Your Current Organism:
Prochlorococcus sp. MIT0601
NCBI taxonomy Id: 1499498
Other names: P. sp. MIT 0601, Prochlorococcus sp. MIT 0601
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