U14_00127 protein (Moduliflexus flocculans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

U14_00127

Hypothetical protein. (522 aa)

Predicted Functional Partners:

U14_05185

0.919

U14_03886

0.810

U14_05015

0.810

U14_05016

0.810

U14_05132

0.810

U14_03907

0.774

U14_03882

0.738

U14_05984

0.621

U14_00427

0.599

U14_02272

0.563

Your Current Organism:

Moduliflexus flocculans

NCBI taxonomy Id: 1499966
Other names: C. Moduliflexus flocculans, Candidatus Moduliflexus flocculans, bacterium UASB14

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
U14_00127	U14_00427	Hypothetical protein.	Hypothetical protein.	0.599
U14_00127	U14_02272	Hypothetical protein.	Hypothetical protein.	0.563
U14_00127	U14_03882	Hypothetical protein.	Hypothetical protein.	0.738
U14_00127	U14_03886	Hypothetical protein.	Hypothetical protein.	0.810
U14_00127	U14_03907	Hypothetical protein.	Hypothetical protein.	0.774
U14_00127	U14_05015	Hypothetical protein.	Hypothetical protein.	0.810
U14_00127	U14_05016	Hypothetical protein.	Hypothetical protein.	0.810
U14_00127	U14_05132	Hypothetical protein.	Hypothetical protein.	0.810
U14_00127	U14_05185	Hypothetical protein.	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.	0.919
U14_00127	U14_05984	Hypothetical protein.	Hypothetical protein.	0.621
U14_00427	U14_00127	Hypothetical protein.	Hypothetical protein.	0.599
U14_00427	U14_03882	Hypothetical protein.	Hypothetical protein.	0.503
U14_00427	U14_03886	Hypothetical protein.	Hypothetical protein.	0.703
U14_00427	U14_03907	Hypothetical protein.	Hypothetical protein.	0.425
U14_00427	U14_05015	Hypothetical protein.	Hypothetical protein.	0.707
U14_00427	U14_05016	Hypothetical protein.	Hypothetical protein.	0.706
U14_00427	U14_05132	Hypothetical protein.	Hypothetical protein.	0.705
U14_02272	U14_00127	Hypothetical protein.	Hypothetical protein.	0.563
U14_02272	U14_03882	Hypothetical protein.	Hypothetical protein.	0.451
U14_02272	U14_03907	Hypothetical protein.	Hypothetical protein.	0.593

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

26

PPI enrichment p-value:

3.23e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

8 of 17

2.07

4.9

2.49e-12

GO:2001295

malonyl-CoA biosynthetic process

2 of 4

2.1

0.96

0.0159

GO:0044281

Small molecule metabolic process

9 of 458

0.69

0.58

0.00035

GO:0071704

Organic substance metabolic process

11 of 1212

0.36

0.29

0.0098

GO:0044238

Primary metabolic process

10 of 999

0.4

0.29

0.0198

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 7

2.16

2.31

2.74e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 41

1.48

1.52

0.00014

GO:0000036

Acyl carrier activity

2 of 2

2.4

1.02

0.0133

GO:0003989

acetyl-CoA carboxylase activity

2 of 3

2.22

1.01

0.0133

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 5

2.0

0.93

0.0169

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 4

2.1

1.07

0.0096

GO:0005737

Cytoplasm

11 of 997

0.44

0.36

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1342

Fatty acid metabolism, and Alpha/beta hydrolase fold

7 of 13

2.13

4.56

6.41e-11

CL:1345

Fatty acid metabolism

4 of 8

2.1

2.57

5.86e-06

CL:1199

Mixed, incl. Pyruvate metabolism, and Citrate cycle (TCA cycle)

8 of 91

1.34

1.94

6.37e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pace01212

Fatty acid metabolism

6 of 10

2.18

4.29

5.66e-10

pace00061

Fatty acid biosynthesis

6 of 10

2.18

4.29

5.66e-10

pace00780

Biotin metabolism

4 of 11

1.96

2.46

5.80e-06

pace01100

Metabolic pathways

9 of 530

0.63

0.53

0.00035

pace01110

Biosynthesis of secondary metabolites

5 of 249

0.7

0.42

0.0351

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

2 of 4

2.1

0.84

0.0276

GOCC:0005737

Cytoplasm

10 of 756

0.52

0.39

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

5 of 9

2.14

3.49

4.57e-08

KW-0444

Lipid biosynthesis

6 of 21

1.85

3.07

4.33e-08

KW-0596

Phosphopantetheine

2 of 2

2.4

1.33

0.0035

KW-0012

Acyltransferase

3 of 24

1.5

1.05

0.0044

KW-0963

Cytoplasm

6 of 253

0.77

0.56

0.0057

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01039

Carboxyl transferase domain

2 of 2

2.4

0.77

0.0390

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2024

Credits

Access

Info

About