U14_00391 protein (Moduliflexus flocculans) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

U14_00391

N-acetylmuramoyl-L-alanine amidase. (475 aa)

Predicted Functional Partners:

U14_03378

0.983

U14_03811

0.979

U14_05987

0.962

U14_02599

0.921

U14_01149

0.908

U14_02361

0.908

U14_03678

0.908

U14_04312

0.904

U14_01905

0.900

U14_01725

0.887

Your Current Organism:

Moduliflexus flocculans

NCBI taxonomy Id: 1499966
Other names: C. Moduliflexus flocculans, Candidatus Moduliflexus flocculans, bacterium UASB14

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
U14_00391	U14_01149	N-acetylmuramoyl-L-alanine amidase.	Rhomboid-like protein.	0.908
U14_00391	U14_01725	N-acetylmuramoyl-L-alanine amidase.	Conserved uncharacterized protein.	0.887
U14_00391	U14_01905	N-acetylmuramoyl-L-alanine amidase.	Hypothetical protein.	0.900
U14_00391	U14_02361	N-acetylmuramoyl-L-alanine amidase.	Hypothetical protein.	0.908
U14_00391	U14_02599	N-acetylmuramoyl-L-alanine amidase.	Rhomboid family protein.	0.921
U14_00391	U14_03378	N-acetylmuramoyl-L-alanine amidase.	Hypothetical protein.	0.983
U14_00391	U14_03678	N-acetylmuramoyl-L-alanine amidase.	Rhomboid family protein.	0.908
U14_00391	U14_03811	N-acetylmuramoyl-L-alanine amidase.	Hypothetical protein.	0.979
U14_00391	U14_04312	N-acetylmuramoyl-L-alanine amidase.	Outer membrane lipoprotein carrier protein.	0.904
U14_00391	U14_05987	N-acetylmuramoyl-L-alanine amidase.	Hypothetical WD-repeat protein alr2800.	0.962
U14_01149	U14_00391	Rhomboid-like protein.	N-acetylmuramoyl-L-alanine amidase.	0.908
U14_01725	U14_00391	Conserved uncharacterized protein.	N-acetylmuramoyl-L-alanine amidase.	0.887
U14_01725	U14_01905	Conserved uncharacterized protein.	Hypothetical protein.	0.401
U14_01905	U14_00391	Hypothetical protein.	N-acetylmuramoyl-L-alanine amidase.	0.900
U14_01905	U14_01725	Hypothetical protein.	Conserved uncharacterized protein.	0.401
U14_02361	U14_00391	Hypothetical protein.	N-acetylmuramoyl-L-alanine amidase.	0.908
U14_02599	U14_00391	Rhomboid family protein.	N-acetylmuramoyl-L-alanine amidase.	0.921
U14_02599	U14_03678	Rhomboid family protein.	Rhomboid family protein.	0.767
U14_03378	U14_00391	Hypothetical protein.	N-acetylmuramoyl-L-alanine amidase.	0.983
U14_03678	U14_00391	Rhomboid family protein.	N-acetylmuramoyl-L-alanine amidase.	0.908

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.822

expected number of edges:

25

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

5 of 11

1.68

1.97

2.18e-05

GO:0009059

Macromolecule biosynthetic process

11 of 165

0.85

0.89

5.45e-07

GO:0010467

Gene expression

11 of 181

0.81

0.83

7.29e-07

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 226

0.71

0.68

5.21e-06

GO:0006412

Translation

6 of 99

0.81

0.55

0.0099

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 5

1.93

1.8

0.00021

GO:0003735

Structural constituent of ribosome

6 of 52

1.09

1.0

0.00035

GO:0019843

rRNA binding

5 of 41

1.11

0.91

0.0017

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.02

0.91

0.0189

GO:0003723

RNA binding

6 of 96

0.82

0.59

0.0062

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 5

1.93

2.07

4.57e-05

GO:0005840

Ribosome

6 of 54

1.07

1.05

0.00012

GO:0032991

Protein-containing complex

6 of 103

0.79

0.63

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:175

RNA polymerase

4 of 5

1.93

2.32

1.12e-05

CL:50

Ribosome, and RNA polymerase

10 of 68

1.19

1.71

2.58e-09

CL:62

Ribosome

6 of 33

1.28

1.52

8.80e-06

CL:38

Mixed, incl. Translation, and Organophosphate metabolic process

11 of 167

0.84

0.92

3.54e-08

CL:64

rRNA-binding

3 of 27

1.07

0.59

0.0315

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dpn03020

RNA polymerase

4 of 4

2.02

2.29

2.01e-05

dpn03010

Ribosome

6 of 51

1.1

1.07

0.00013

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 27

1.2

0.99

0.0015

MAP-5663205

Infectious disease

4 of 30

1.15

0.95

0.0015

MAP-1643685

Disease

4 of 32

1.12

0.93

0.0015

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 18

1.37

0.99

0.0045

GOCC:0005840

Ribosome

5 of 42

1.1

0.81

0.0045

GOCC:0043229

Intracellular organelle

6 of 135

0.67

0.45

0.0140

GOCC:0005622

Intracellular

11 of 529

0.34

0.29

0.0059

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 5

1.93

1.97

8.22e-05

KW-0548

Nucleotidyltransferase

4 of 23

1.26

1.05

0.0015

KW-0804

Transcription

5 of 36

1.17

1.04

0.00064

KW-0699

rRNA-binding

5 of 39

1.13

1.0

0.00073

KW-0689

Ribosomal protein

6 of 53

1.08

0.99

0.00038

(more ...)

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