U14_03427 protein (Moduliflexus flocculans) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

U14_03427

Tetratricopeptide TPR_2. (494 aa)

Predicted Functional Partners:

U14_00565

0.849

U14_06033

0.834

U14_03868

0.833

U14_04416

0.812

U14_05483

0.795

U14_05439

0.778

U14_03080

0.768

U14_00642

0.764

U14_03049

0.760

U14_04257

0.759

Your Current Organism:

Moduliflexus flocculans

NCBI taxonomy Id: 1499966
Other names: C. Moduliflexus flocculans, Candidatus Moduliflexus flocculans, bacterium UASB14

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
U14_00565	U14_00642	Tetratricopeptide repeat family.	Hypothetical protein.	0.775
U14_00565	U14_03049	Tetratricopeptide repeat family.	Hypothetical protein.	0.708
U14_00565	U14_03080	Tetratricopeptide repeat family.	Hypothetical protein.	0.809
U14_00565	U14_03427	Tetratricopeptide repeat family.	Tetratricopeptide TPR_2.	0.849
U14_00565	U14_03868	Tetratricopeptide repeat family.	Chromosome segregation ATPases.	0.813
U14_00565	U14_04257	Tetratricopeptide repeat family.	Predicted phosphosugar isomerase; Predicted P-loop-containing kinase.	0.793
U14_00565	U14_04416	Tetratricopeptide repeat family.	ATPase.	0.809
U14_00565	U14_05439	Tetratricopeptide repeat family.	PBS lyase HEAT-like repeat protein.	0.941
U14_00565	U14_05483	Tetratricopeptide repeat family.	Tetratricopeptide repeat domain protein; Fragment.	0.801
U14_00565	U14_06033	Tetratricopeptide repeat family.	Peptidase C14 caspase catalytic subunit p20.	0.810
U14_00642	U14_00565	Hypothetical protein.	Tetratricopeptide repeat family.	0.775
U14_00642	U14_03049	Hypothetical protein.	Hypothetical protein.	0.654
U14_00642	U14_03080	Hypothetical protein.	Hypothetical protein.	0.774
U14_00642	U14_03427	Hypothetical protein.	Tetratricopeptide TPR_2.	0.764
U14_00642	U14_03868	Hypothetical protein.	Chromosome segregation ATPases.	0.775
U14_00642	U14_04257	Hypothetical protein.	Predicted phosphosugar isomerase; Predicted P-loop-containing kinase.	0.775
U14_00642	U14_04416	Hypothetical protein.	ATPase.	0.771
U14_00642	U14_05439	Hypothetical protein.	PBS lyase HEAT-like repeat protein.	0.773
U14_00642	U14_05483	Hypothetical protein.	Tetratricopeptide repeat domain protein; Fragment.	0.766
U14_00642	U14_06033	Hypothetical protein.	Peptidase C14 caspase catalytic subunit p20.	0.768

page 1 of 6

Network Stats

number of nodes:

6

number of edges:

7

average node degree:

2.33

avg. local clustering coefficient:

0.867

expected number of edges:

5

PPI enrichment p-value:

0.281

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

7 of 101

1.71

2.76

6.02e-08

GO:0006635

Fatty acid beta-oxidation

4 of 29

2.01

2.21

2.97e-05

GO:0046395

Carboxylic acid catabolic process

5 of 111

1.53

1.66

6.47e-05

GO:0140647

P450-containing electron transport chain

2 of 2

2.87

1.53

0.0017

GO:0010124

Phenylacetate catabolic process

2 of 2

2.87

1.53

0.0017

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003857

3-hydroxyacyl-CoA dehydrogenase activity

2 of 2

2.87

1.02

0.0143

GO:0003988

acetyl-CoA C-acyltransferase activity

2 of 5

2.47

1.01

0.0143

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

4 of 123

1.38

0.82

0.0143

GO:0016491

Oxidoreductase activity

6 of 689

0.81

0.49

0.0279

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

3 of 67

1.52

0.7

0.0379

GO:0005739

Mitochondrion

7 of 822

0.8

0.51

0.0195

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8342

Fatty acid beta-oxidation, and Acyl-CoA dehydrogenase, conserved site

4 of 17

2.24

2.65

6.17e-06

CL:8692

Mixed, incl. Lipoate metabolic process, and Ergot alkaloid metabolic process

3 of 5

2.65

2.61

1.44e-05

CL:8329

Mixed, incl. Fatty acid catabolic process, and Branched-chain amino acid catabolism

5 of 47

1.9

2.41

5.42e-06

CL:8316

Mixed, incl. Fatty acid degradation, and NAD(P)-binding domain superfamily

6 of 135

1.52

1.92

6.17e-06

CL:8360

Beta-oxidation of very long chain fatty acids, and Beta oxidation of butanoyl-CoA to acetyl-CoA

2 of 8

2.27

1.18

0.0064

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01212

Fatty acid metabolism

4 of 96

1.49

1.37

0.00049

map00061

Fatty acid biosynthesis

2 of 19

1.89

0.92

0.0171

map00592

alpha-Linolenic acid metabolism

2 of 24

1.79

0.9

0.0171

map00190

Oxidative phosphorylation

3 of 116

1.29

0.76

0.0171

map00071

Fatty acid degradation

2 of 45

1.52

0.7

0.0371

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-390247

Beta-oxidation of very long chain fatty acids

3 of 7

2.5

2.18

8.67e-05

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

3 of 13

2.24

1.95

0.00018

MAP-2046104

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

3 of 13

2.24

1.95

0.00018

MAP-8978868

Fatty acid metabolism

6 of 138

1.51

1.85

1.03e-05

MAP-77289

Mitochondrial Fatty Acid Beta-Oxidation

3 of 25

1.95

1.56

0.00075

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02803

Thiolase, C-terminal domain

2 of 4

2.57

1.02

0.0141

PF00108

Thiolase, N-terminal domain

2 of 3

2.7

1.02

0.0141

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016039

Thiolase-like

3 of 19

2.07

1.13

0.0070

IPR020613

Thiolase, conserved site

2 of 3

2.7

0.93

0.0210

IPR020617

Thiolase, C-terminal

2 of 4

2.57

0.92

0.0210

IPR020616

Thiolase, N-terminal

2 of 4

2.57

0.92

0.0210

IPR002155

Thiolase

2 of 4

2.57

0.92

0.0210

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