U14_04465 protein (Moduliflexus flocculans) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

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Score

U14_04465

UPF0102 protein Gmet_2864; Belongs to the UPF0102 family. (121 aa)

Predicted Functional Partners:

U14_03276

0.869

U14_04190

0.838

U14_02231

0.815

U14_05895

0.768

U14_01465

0.672

U14_04653

0.672

U14_00585

0.671

U14_02537

0.671

U14_01756

0.664

U14_02890

0.664

Your Current Organism:

Moduliflexus flocculans

NCBI taxonomy Id: 1499966
Other names: C. Moduliflexus flocculans, Candidatus Moduliflexus flocculans, bacterium UASB14

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
U14_00585	U14_01465	Protein serine phosphatase with GAF(S) sensor(S).	PAS fold family.	0.987
U14_00585	U14_01756	Protein serine phosphatase with GAF(S) sensor(S).	Sensory box histidine kinase/response regulator.	0.962
U14_00585	U14_02231	Protein serine phosphatase with GAF(S) sensor(S).	Putative enzyme, N-terminal; Transcriptional regulator with P-loop containing NTP hydrolase.	0.705
U14_00585	U14_02537	Protein serine phosphatase with GAF(S) sensor(S).	Serine phosphatase.	0.968
U14_00585	U14_02890	Protein serine phosphatase with GAF(S) sensor(S).	Putative two-component system sensor protein.	0.962
U14_00585	U14_03276	Protein serine phosphatase with GAF(S) sensor(S).	Amidophosphoribosyltransferase-like protein.	0.705
U14_00585	U14_04190	Protein serine phosphatase with GAF(S) sensor(S).	DNA protecting protein DprA.	0.714
U14_00585	U14_04465	Protein serine phosphatase with GAF(S) sensor(S).	UPF0102 protein Gmet_2864; Belongs to the UPF0102 family.	0.671
U14_00585	U14_04653	Protein serine phosphatase with GAF(S) sensor(S).	Diguanylate cyclase with PAS/PAC and GAF sensors.	0.987
U14_00585	U14_05895	Protein serine phosphatase with GAF(S) sensor(S).	Metallo-beta-lactamase superfamily.	0.722
U14_01465	U14_00585	PAS fold family.	Protein serine phosphatase with GAF(S) sensor(S).	0.987
U14_01465	U14_01756	PAS fold family.	Sensory box histidine kinase/response regulator.	0.994
U14_01465	U14_02537	PAS fold family.	Serine phosphatase.	0.987
U14_01465	U14_02890	PAS fold family.	Putative two-component system sensor protein.	0.994
U14_01465	U14_03276	PAS fold family.	Amidophosphoribosyltransferase-like protein.	0.714
U14_01465	U14_04190	PAS fold family.	DNA protecting protein DprA.	0.672
U14_01465	U14_04465	PAS fold family.	UPF0102 protein Gmet_2864; Belongs to the UPF0102 family.	0.672
U14_01465	U14_04653	PAS fold family.	Diguanylate cyclase with PAS/PAC and GAF sensors.	0.990
U14_01465	U14_05895	PAS fold family.	Metallo-beta-lactamase superfamily.	0.719
U14_01756	U14_00585	Sensory box histidine kinase/response regulator.	Protein serine phosphatase with GAF(S) sensor(S).	0.962

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.897

expected number of edges:

21

PPI enrichment p-value:

0.000633

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000413

Protein peptidyl-prolyl isomerization

3 of 3

2.71

2.05

0.00017

GO:0006457

Protein folding

3 of 26

1.77

1.23

0.0030

GO:0006412

Translation

5 of 125

1.31

1.16

0.00077

GO:0019538

Protein metabolic process

8 of 414

0.99

0.93

0.00017

GO:0009059

Macromolecule biosynthetic process

6 of 288

1.02

0.84

0.0016

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003755

Peptidyl-prolyl cis-trans isomerase activity

3 of 8

2.28

1.64

0.00080

GO:0019843

rRNA binding

4 of 42

1.68

1.43

0.00080

GO:0003735

Structural constituent of ribosome

4 of 57

1.55

1.33

0.00086

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

4 of 63

1.51

1.4

0.00044

GO:0043226

Organelle

6 of 234

1.11

1.03

0.00034

GO:0043229

Intracellular organelle

5 of 185

1.14

0.99

0.00085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:773

Mixed, incl. Protein peptidyl-prolyl isomerization, and DEAD-like helicases superfamily

6 of 15

2.31

4.44

7.51e-10

CL:180

Ribosome

4 of 31

1.82

1.91

7.53e-05

CL:166

Ribosome, and Translational elongation

5 of 73

1.54

1.7

5.15e-05

CL:182

rRNA-binding

3 of 24

1.8

1.45

0.00098

CL:775

DEAD-like helicases superfamily, and UmuC domain

2 of 5

2.31

1.27

0.0043

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lagg03010

Ribosome

4 of 55

1.57

1.45

0.00042

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

4 of 48

1.63

1.42

0.00068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0697

Rotamase

3 of 7

2.34

2.02

0.00015

KW-0699

rRNA-binding

4 of 39

1.72

0.00015

KW-0689

Ribosomal protein

4 of 58

1.54

1.46

0.00033

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00160

Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

2 of 2

2.71

0.99

0.0159

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044666

Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like

2 of 2

2.71

0.78

0.0384

IPR029000

Cyclophilin-like domain superfamily

2 of 3

2.53

0.78

0.0384

IPR002130

Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain

2 of 2

2.71

0.78

0.0384

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