U27_00216 protein (Vecturithrix granuli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

U27_00216

Binding-protein-dependent transport systems inner membrane component. (292 aa)

Predicted Functional Partners:

U27_00217

0.981

U27_06558

0.978

U27_06556

0.976

U27_02941

0.972

U27_06849

0.925

U27_04765

0.922

U27_06825

0.920

U27_04151

0.919

U27_05649

0.919

U27_06142

0.919

Your Current Organism:

Vecturithrix granuli

NCBI taxonomy Id: 1499967
Other names: C. Vecturithrix granuli, Candidatus Vecturithrix granuli, bacterium UASB270

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
U27_00216	U27_00217	Binding-protein-dependent transport systems inner membrane component.	Binding-protein-dependent transport systems inner membrane component.	0.981
U27_00216	U27_02941	Binding-protein-dependent transport systems inner membrane component.	Extracellular solute-binding protein family 1.	0.972
U27_00216	U27_04151	Binding-protein-dependent transport systems inner membrane component.	SN-glycerol-3-phosphate transport system permease protein.	0.919
U27_00216	U27_04765	Binding-protein-dependent transport systems inner membrane component.	Sugar ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily.	0.922
U27_00216	U27_05649	Binding-protein-dependent transport systems inner membrane component.	Binding-protein-dependent transport systems inner membrane component.	0.919
U27_00216	U27_06142	Binding-protein-dependent transport systems inner membrane component.	Binding-protein-dependent transport systems inner membrane component.	0.919
U27_00216	U27_06556	Binding-protein-dependent transport systems inner membrane component.	Extracellular solute-binding protein family 1.	0.976
U27_00216	U27_06558	Binding-protein-dependent transport systems inner membrane component.	Binding-protein-dependent transport systems inner membrane component.	0.978
U27_00216	U27_06825	Binding-protein-dependent transport systems inner membrane component.	Sugar ABC transporter, permease-like protein.	0.920
U27_00216	U27_06849	Binding-protein-dependent transport systems inner membrane component.	ABC transporter, permease protein.	0.925
U27_00217	U27_00216	Binding-protein-dependent transport systems inner membrane component.	Binding-protein-dependent transport systems inner membrane component.	0.981
U27_00217	U27_02941	Binding-protein-dependent transport systems inner membrane component.	Extracellular solute-binding protein family 1.	0.467
U27_00217	U27_04765	Binding-protein-dependent transport systems inner membrane component.	Sugar ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily.	0.902
U27_00217	U27_06556	Binding-protein-dependent transport systems inner membrane component.	Extracellular solute-binding protein family 1.	0.467
U27_00217	U27_06558	Binding-protein-dependent transport systems inner membrane component.	Binding-protein-dependent transport systems inner membrane component.	0.524
U27_02941	U27_00216	Extracellular solute-binding protein family 1.	Binding-protein-dependent transport systems inner membrane component.	0.972
U27_02941	U27_00217	Extracellular solute-binding protein family 1.	Binding-protein-dependent transport systems inner membrane component.	0.467
U27_02941	U27_04151	Extracellular solute-binding protein family 1.	SN-glycerol-3-phosphate transport system permease protein.	0.467
U27_02941	U27_04765	Extracellular solute-binding protein family 1.	Sugar ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily.	0.978
U27_02941	U27_05649	Extracellular solute-binding protein family 1.	Binding-protein-dependent transport systems inner membrane component.	0.467

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.808

expected number of edges:

10

PPI enrichment p-value:

0.0388

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006465

Signal peptide processing

5 of 9

2.73

4.69

1.35e-09

GO:0016485

Protein processing

6 of 30

2.28

4.3

1.35e-09

GO:0006508

Proteolysis

8 of 527

1.16

1.36

4.32e-06

GO:0006627

Protein processing involved in protein targeting to mitochondrion

2 of 4

2.68

1.21

0.0063

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008236

Serine-type peptidase activity

7 of 171

1.59

2.5

6.78e-08

GO:0008233

Peptidase activity

9 of 331

1.42

2.32

2.20e-09

GO:0004252

Serine-type endopeptidase activity

6 of 136

1.63

2.32

7.37e-07

GO:0070006

Metalloaminopeptidase activity

2 of 11

2.24

1.03

0.0122

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042720

Mitochondrial inner membrane peptidase complex

2 of 2

2.98

1.41

0.0028

GO:0031090

Organelle membrane

7 of 802

0.92

0.71

0.0028

GO:0016020

Membrane

8 of 1882

0.61

0.39

0.0248

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11432

Mixed, incl. Prolyl oligopeptidase family, and Signal peptide processing

9 of 43

2.3

7.16

5.83e-17

CL:11480

Signal peptide processing, and Regulation of TOR signaling

6 of 18

2.51

5.45

1.40e-11

CL:11482

Regulation of TOR signaling, and Peptidase S26A, signal peptidase I

3 of 11

2.42

2.13

9.98e-05

CL:11439

Creatinase/Aminopeptidase P/Spt16, N-terminal, and Prolyl oligopeptidase family

3 of 11

2.42

2.13

9.98e-05

CL:1398

PB1 domain, and G-protein, beta subunit

2 of 5

2.58

1.35

0.0034

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

6 of 29

2.3

4.9

5.39e-11

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2980736

Peptide hormone metabolism

3 of 21

2.14

1.48

0.0015

MAP-392499

Metabolism of proteins

6 of 787

0.86

0.52

0.0261

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005787

Signal peptidase complex

3 of 6

2.68

2.29

6.06e-05

GOCC:0098796

Membrane protein complex

6 of 264

1.34

1.44

6.06e-05

GOCC:0042720

Mitochondrial inner membrane peptidase complex

2 of 3

2.81

1.41

0.0028

GOCC:0005743

Mitochondrial inner membrane

3 of 124

1.37

0.69

0.0321

GOCC:0019898

Extrinsic component of membrane

2 of 36

1.73

0.68

0.0488

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

3 of 48

1.78

1.39

0.0013

KW-0645

Protease

5 of 244

1.29

1.23

0.00032

KW-0378

Hydrolase

7 of 690

0.99

0.9

0.00031

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00717

Peptidase S24-like

4 of 4

2.98

4.04

3.75e-08

PF00557

Metallopeptidase family M24

2 of 10

2.28

0.85

0.0274

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036286

LexA/Signal peptidase-like superfamily

5 of 5

2.98

5.18

2.57e-10

IPR019533

Peptidase S26

5 of 5

2.98

5.18

2.57e-10

IPR019758

Peptidase S26A, signal peptidase I, conserved site

3 of 3

2.98

2.67

1.36e-05

IPR001733

Peptidase S26B

3 of 3

2.98

2.67

1.36e-05

IPR019756

Peptidase S26A, signal peptidase I, serine active site

2 of 2

2.98

1.4

0.0029

(more ...)

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