U27_01499 protein (Vecturithrix granuli) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

U27_01499

UPF0365 protein Ftrac_3711. (333 aa)

Predicted Functional Partners:

U27_01500

0.991

U27_02706

0.701

U27_02707

0.701

U27_01097

0.632

U27_01306

0.632

U27_01498

0.590

U27_02041

0.569

U27_01071

0.523

U27_02696

0.523

ftsH

0.403

Your Current Organism:

Vecturithrix granuli

NCBI taxonomy Id: 1499967
Other names: C. Vecturithrix granuli, Candidatus Vecturithrix granuli, bacterium UASB270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
U27_01071	U27_01097	U27_01071	U27_01097	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	Putative transmembrane anti-sigma factor.	0.470
U27_01071	U27_01306	U27_01071	U27_01306	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	Predicted transmembrane transcriptional regulator (anti-sigma factor).	0.470
U27_01071	U27_01499	U27_01071	U27_01499	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	UPF0365 protein Ftrac_3711.	0.523
U27_01071	U27_01500	U27_01071	U27_01500	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	Hypothetical protein.	0.522
U27_01071	U27_02041	U27_01071	U27_02041	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	Hypothetical protein.	0.535
U27_01097	U27_01071	U27_01097	U27_01071	Putative transmembrane anti-sigma factor.	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	0.470
U27_01097	U27_01499	U27_01097	U27_01499	Putative transmembrane anti-sigma factor.	UPF0365 protein Ftrac_3711.	0.632
U27_01097	U27_01500	U27_01097	U27_01500	Putative transmembrane anti-sigma factor.	Hypothetical protein.	0.583
U27_01097	U27_02696	U27_01097	U27_02696	Putative transmembrane anti-sigma factor.	Aspartate racemase subfamily protein.	0.470
U27_01097	ftsH	U27_01097	U27_02298	Putative transmembrane anti-sigma factor.	ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.421
U27_01306	U27_01071	U27_01306	U27_01071	Predicted transmembrane transcriptional regulator (anti-sigma factor).	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	0.470
U27_01306	U27_01499	U27_01306	U27_01499	Predicted transmembrane transcriptional regulator (anti-sigma factor).	UPF0365 protein Ftrac_3711.	0.632
U27_01306	U27_01500	U27_01306	U27_01500	Predicted transmembrane transcriptional regulator (anti-sigma factor).	Hypothetical protein.	0.583
U27_01306	U27_02696	U27_01306	U27_02696	Predicted transmembrane transcriptional regulator (anti-sigma factor).	Aspartate racemase subfamily protein.	0.470
U27_01306	ftsH	U27_01306	U27_02298	Predicted transmembrane transcriptional regulator (anti-sigma factor).	ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.421
U27_01498	U27_01499	U27_01498	U27_01499	Hypothetical protein.	UPF0365 protein Ftrac_3711.	0.590
U27_01498	U27_01500	U27_01498	U27_01500	Hypothetical protein.	Hypothetical protein.	0.564
U27_01499	U27_01071	U27_01499	U27_01071	UPF0365 protein Ftrac_3711.	Aspartate racemase; Belongs to the aspartate/glutamate racemases family.	0.523
U27_01499	U27_01097	U27_01499	U27_01097	UPF0365 protein Ftrac_3711.	Putative transmembrane anti-sigma factor.	0.632
U27_01499	U27_01306	U27_01499	U27_01306	UPF0365 protein Ftrac_3711.	Predicted transmembrane transcriptional regulator (anti-sigma factor).	0.632

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.871

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070372

Regulation of ERK1 and ERK2 cascade

3 of 8

2.8

2.19

0.00010

GO:0043065

Positive regulation of apoptotic process

3 of 12

2.63

2.09

0.00014

GO:2001233

Regulation of apoptotic signaling pathway

3 of 17

2.48

2.06

0.00014

GO:0007219

Notch signaling pathway

3 of 17

2.48

2.06

0.00014

GO:0043410

Positive regulation of MAPK cascade

3 of 19

2.43

2.05

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 937

1.1

1.05

0.00020

GO:0000151

Ubiquitin ligase complex

3 of 112

1.66

0.96

0.0107

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:391

Mostly uncharacterized, incl. STIMATE family, and Phototransduction

5 of 23

2.57

4.36

4.02e-09

CL:385

Mixed, incl. RAC1 GTPase cycle, and Negative regulation of glycogen metabolic process

6 of 69

2.17

3.95

4.02e-09

CL:5755

Ubiquitin homologues, and Zinc finger, SIAH-type

3 of 15

2.53

2.45

2.64e-05

CL:393

Mixed, incl. STIMATE family, and Phototransduction

3 of 15

2.53

2.45

2.64e-05

CL:396

Mixed, incl. STIMATE family, and Phototransduction

2 of 7

2.68

1.55

0.0015

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1280218

Adaptive Immune System

7 of 442

1.43

1.91

1.36e-06

MAP-168256

Immune System

7 of 1083

1.04

0.95

0.00031

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000151

Ubiquitin ligase complex

3 of 114

1.65

0.68

0.0462

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03145

Seven in absentia protein family

2 of 2

3.23

1.31

0.0043

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018121

Seven-in-absentia protein, TRAF-like domain

2 of 2

3.23

1.07

0.0121

IPR013010

Zinc finger, SIAH-type

2 of 2

3.23

1.07

0.0121

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