U27_03067 protein (Vecturithrix granuli) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

U27_03067

WD-40 repeat protein. (965 aa)

Predicted Functional Partners:

U27_01387

0.960

U27_04999

0.938

U27_03873

0.937

alaS

0.935

U27_05676

0.935

U27_04604

0.918

U27_01972

0.915

U27_04905

0.915

U27_05732

0.906

U27_00108

0.902

Your Current Organism:

Vecturithrix granuli

NCBI taxonomy Id: 1499967
Other names: C. Vecturithrix granuli, Candidatus Vecturithrix granuli, bacterium UASB270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
U27_00108	U27_01387	U27_00108	U27_01387	Internalin A.	Helicase domain protein.	0.616
U27_00108	U27_01972	U27_00108	U27_01972	Internalin A.	Pfs, NACHT and Ankyrin domain protein.	0.966
U27_00108	U27_03067	U27_00108	U27_03067	Internalin A.	WD-40 repeat protein.	0.902
U27_00108	U27_04905	U27_00108	U27_04905	Internalin A.	Ankyrin.	0.962
U27_00108	U27_04999	U27_00108	U27_04999	Internalin A.	Helicase-like.	0.944
U27_01387	U27_00108	U27_01387	U27_00108	Helicase domain protein.	Internalin A.	0.616
U27_01387	U27_01972	U27_01387	U27_01972	Helicase domain protein.	Pfs, NACHT and Ankyrin domain protein.	0.653
U27_01387	U27_03067	U27_01387	U27_03067	Helicase domain protein.	WD-40 repeat protein.	0.960
U27_01387	U27_03873	U27_01387	U27_03873	Helicase domain protein.	Metallo-beta-lactamase family protein RNase.	0.946
U27_01387	U27_04604	U27_01387	U27_04604	Helicase domain protein.	Histone deacetylase/AcuC/AphA family protein.	0.492
U27_01387	U27_04905	U27_01387	U27_04905	Helicase domain protein.	Ankyrin.	0.653
U27_01387	U27_04999	U27_01387	U27_04999	Helicase domain protein.	Helicase-like.	0.993
U27_01387	U27_05732	U27_01387	U27_05732	Helicase domain protein.	Histone deacetylase superfamily.	0.492
U27_01972	U27_00108	U27_01972	U27_00108	Pfs, NACHT and Ankyrin domain protein.	Internalin A.	0.966
U27_01972	U27_01387	U27_01972	U27_01387	Pfs, NACHT and Ankyrin domain protein.	Helicase domain protein.	0.653
U27_01972	U27_03067	U27_01972	U27_03067	Pfs, NACHT and Ankyrin domain protein.	WD-40 repeat protein.	0.915
U27_01972	U27_03873	U27_01972	U27_03873	Pfs, NACHT and Ankyrin domain protein.	Metallo-beta-lactamase family protein RNase.	0.481
U27_01972	U27_04604	U27_01972	U27_04604	Pfs, NACHT and Ankyrin domain protein.	Histone deacetylase/AcuC/AphA family protein.	0.911
U27_01972	U27_04999	U27_01972	U27_04999	Pfs, NACHT and Ankyrin domain protein.	Helicase-like.	0.943
U27_01972	U27_05676	U27_01972	U27_05676	Pfs, NACHT and Ankyrin domain protein.	Truncated alanyl-tRNA synthetase.	0.902

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.817

expected number of edges:

12

PPI enrichment p-value:

1.52e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019557

Histidine catabolic process to glutamate and formate

3 of 3

2.61

2.18

9.31e-05

GO:0019556

Histidine catabolic process to glutamate and formamide

3 of 3

2.61

2.18

9.31e-05

GO:0017000

Antibiotic biosynthetic process

5 of 34

1.77

2.07

2.19e-05

GO:0043648

Dicarboxylic acid metabolic process

4 of 41

1.6

1.48

0.00040

GO:0009064

Glutamine family amino acid metabolic process

4 of 51

1.5

1.31

0.00080

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

5 of 17

2.08

2.97

5.91e-07

GO:0003824

Catalytic activity

11 of 2131

0.32

0.24

0.0448

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1345

0.48

0.36

0.0068

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:363

Histidine metabolism, and Polyamine biosynthesis

4 of 8

2.31

2.77

4.06e-06

CL:729

Phosphopantetheine binding, and Cytochrome P450, B-class

5 of 24

1.93

2.51

3.49e-06

CL:732

Phosphopantetheine binding, and Phosphopantetheine attachment site

3 of 18

1.83

1.43

0.0012

CL:157

Biosynthesis of amino acids, and Arginine and proline metabolism

5 of 111

1.26

1.18

0.00039

CL:751

Phosphopantetheine binding

2 of 5

2.21

1.16

0.0069

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00340

Histidine metabolism

3 of 14

1.94

1.52

0.00094

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

5 of 35

1.76

2.24

6.41e-06

GOCC:0043231

Intracellular membrane-bounded organelle

6 of 208

1.07

0.96

0.00046

GOCC:0043229

Intracellular organelle

7 of 372

0.88

0.76

0.00057

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0369

Histidine metabolism

4 of 4

2.61

3.46

3.02e-07

KW-0596

Phosphopantetheine

5 of 27

1.87

2.71

6.65e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00501

AMP-binding enzyme

5 of 23

1.94

2.63

1.91e-06

PF00668

Condensation domain

4 of 15

2.03

2.26

2.42e-05

PF13193

AMP-binding enzyme C-terminal domain

4 of 19

1.93

2.11

3.67e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045851

AMP-binding enzyme, C-terminal domain superfamily

5 of 22

1.96

2.52

4.12e-06

IPR020845

AMP-binding, conserved site

5 of 22

1.96

2.52

4.12e-06

IPR000873

AMP-dependent synthetase/ligase domain

5 of 23

1.94

2.5

4.12e-06

IPR009081

Phosphopantetheine binding ACP domain

5 of 27

1.87

2.43

4.12e-06

IPR036736

ACP-like superfamily

5 of 28

1.86

2.42

4.12e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00823

Phosphopantetheine attachment site

3 of 7

2.24

1.95

0.00018

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