U27_04533 protein (Vecturithrix granuli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

U27_04533

Periplasmic binding protein/LacI transcriptional regulator. (313 aa)

Predicted Functional Partners:

U27_01927

0.955

U27_03137

0.955

U27_01292

0.954

U27_05029

0.954

U27_00907

0.953

U27_01201

0.953

U27_01723

0.953

U27_02490

0.953

U27_05336

0.953

U27_06936

0.953

Your Current Organism:

Vecturithrix granuli

NCBI taxonomy Id: 1499967
Other names: C. Vecturithrix granuli, Candidatus Vecturithrix granuli, bacterium UASB270

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
U27_00907	U27_01201	Multi-sensor hybrid histidine kinase.	ATP-binding region ATPase domain protein.	0.989
U27_00907	U27_01292	Multi-sensor hybrid histidine kinase.	Multi-sensor hybrid histidine kinase.	0.994
U27_00907	U27_01723	Multi-sensor hybrid histidine kinase.	Multi-sensor hybrid histidine kinase.	0.989
U27_00907	U27_01927	Multi-sensor hybrid histidine kinase.	Multi-sensor hybrid histidine kinase.	0.995
U27_00907	U27_02490	Multi-sensor hybrid histidine kinase.	Two component system histidine kinase.	0.991
U27_00907	U27_03137	Multi-sensor hybrid histidine kinase.	Chromosome segregation ATPases.	0.995
U27_00907	U27_04533	Multi-sensor hybrid histidine kinase.	Periplasmic binding protein/LacI transcriptional regulator.	0.953
U27_00907	U27_05029	Multi-sensor hybrid histidine kinase.	Diguanylate cyclase/phosphodiesterase with FHA and GAF sensor.	0.995
U27_00907	U27_05336	Multi-sensor hybrid histidine kinase.	Serine/threonine kinase with two-component sensor domain.	0.988
U27_00907	U27_06936	Multi-sensor hybrid histidine kinase.	Two-component hybrid sensor and regulator.	0.991
U27_01201	U27_00907	ATP-binding region ATPase domain protein.	Multi-sensor hybrid histidine kinase.	0.989
U27_01201	U27_01292	ATP-binding region ATPase domain protein.	Multi-sensor hybrid histidine kinase.	0.990
U27_01201	U27_01723	ATP-binding region ATPase domain protein.	Multi-sensor hybrid histidine kinase.	0.988
U27_01201	U27_01927	ATP-binding region ATPase domain protein.	Multi-sensor hybrid histidine kinase.	0.991
U27_01201	U27_02490	ATP-binding region ATPase domain protein.	Two component system histidine kinase.	0.989
U27_01201	U27_03137	ATP-binding region ATPase domain protein.	Chromosome segregation ATPases.	0.994
U27_01201	U27_04533	ATP-binding region ATPase domain protein.	Periplasmic binding protein/LacI transcriptional regulator.	0.953
U27_01201	U27_05029	ATP-binding region ATPase domain protein.	Diguanylate cyclase/phosphodiesterase with FHA and GAF sensor.	0.994
U27_01201	U27_05336	ATP-binding region ATPase domain protein.	Serine/threonine kinase with two-component sensor domain.	0.989
U27_01201	U27_06936	ATP-binding region ATPase domain protein.	Two-component hybrid sensor and regulator.	0.989

page 1 of 6

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000724

Double-strand break repair via homologous recombination

3 of 4

2.43

1.93

0.00054

GO:0006281

DNA repair

4 of 50

1.46

1.23

0.0020

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003690

Double-stranded DNA binding

3 of 14

1.89

1.25

0.0057

GO:0003678

DNA helicase activity

3 of 14

1.89

1.25

0.0057

GO:0004527

Exonuclease activity

3 of 20

1.73

1.2

0.0057

GO:0016887

ATP hydrolysis activity

3 of 41

1.42

0.86

0.0179

GO:0008408

3-5 exonuclease activity

2 of 9

1.9

0.86

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033202

DNA helicase complex

3 of 8

2.13

2.0

0.00027

GO:1902494

Catalytic complex

4 of 68

1.33

1.21

0.00092

GO:0032991

Protein-containing complex

5 of 170

1.03

0.88

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1230

PD-(D/E)XK nuclease superfamily, and CBS domain

4 of 6

2.38

3.11

3.40e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033202

DNA helicase complex

3 of 13

1.92

1.48

0.0020

GOCC:0044815

DNA packaging complex

3 of 15

1.86

1.46

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0269

Exonuclease

3 of 11

1.99

1.9

0.00033

KW-0234

DNA repair

4 of 31

1.67

1.72

0.00024

KW-0227

DNA damage

4 of 31

1.67

1.72

0.00024

KW-0347

Helicase

3 of 20

1.73

1.5

0.0012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13361

UvrD-like helicase C-terminal domain

3 of 3

2.56

2.31

0.00013

PF12705

PD-(D/E)XK nuclease superfamily

3 of 4

2.43

2.28

0.00013

PF13245

AAA domain

2 of 5

2.16

0.99

0.0212

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038726

PD-(D/E)XK endonuclease-like domain, AddAB-type

3 of 4

2.43

1.92

0.00058

IPR011604

PD-(D/E)XK endonuclease-like domain superfamily

3 of 4

2.43

1.92

0.00058

IPR011335

Restriction endonuclease type II-like

3 of 7

2.19

1.82

0.00067

IPR014016

UvrD-like helicase, ATP-binding domain

3 of 8

2.13

1.8

0.00068

IPR000212

DNA helicase, UvrD/REP type

3 of 8

2.13

1.8

0.00068

(more ...)

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