STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (253 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.997
U27_05261
Dihydroorotate dehydrogenase family protein; Belongs to the dihydroorotate dehydrogenase family.
 
 
 0.990
U27_00757
Oxidoreductase FAD/NAD(P)-binding domain protein.
  
 
 0.936
U27_04273
Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate.
  
 
 0.931
U27_06230
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
  
 
 0.931
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 
 0.916
U27_00421
DNA topoisomerase.
   
 
 0.901
U27_01235
Arsenical pump-driving ATPase.
    
 
 0.900
U27_03634
Putative arsenical pump-driving ATPase.
    
 
 0.900
U27_04543
Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
  
  
 0.898
Your Current Organism:
Vecturithrix granuli
NCBI taxonomy Id: 1499967
Other names: C. Vecturithrix granuli, Candidatus Vecturithrix granuli, bacterium UASB270
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