U27_06642 protein (Vecturithrix granuli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

U27_06642

Hypothetical protein. (77 aa)

Predicted Functional Partners:

U27_06639

0.997

U27_06641

0.996

U27_06644

0.994

U27_06643

0.993

U27_06640

0.991

U27_02895

0.989

U27_06646

0.989

U27_06645

0.987

U27_02893

0.985

U27_02886

0.980

Your Current Organism:

Vecturithrix granuli

NCBI taxonomy Id: 1499967
Other names: C. Vecturithrix granuli, Candidatus Vecturithrix granuli, bacterium UASB270

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
U27_02886	U27_02893	NADH dehydrogenase (Quinone).	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	0.994
U27_02886	U27_02895	NADH dehydrogenase (Quinone).	Cation antiporter.	0.994
U27_02886	U27_06639	NADH dehydrogenase (Quinone).	Cation antiporter.	0.992
U27_02886	U27_06640	NADH dehydrogenase (Quinone).	Multiple resistance and pH regulation protein F.	0.978
U27_02886	U27_06641	NADH dehydrogenase (Quinone).	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	0.991
U27_02886	U27_06642	NADH dehydrogenase (Quinone).	Hypothetical protein.	0.980
U27_02886	U27_06643	NADH dehydrogenase (Quinone).	Hypothetical protein.	0.981
U27_02886	U27_06644	NADH dehydrogenase (Quinone).	Na+/H+ antiporter MnhB subunit-related protein.	0.992
U27_02886	U27_06645	NADH dehydrogenase (Quinone).	NADH-ubiquinone oxidoreductase chain 4L.	0.997
U27_02893	U27_02886	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	NADH dehydrogenase (Quinone).	0.994
U27_02893	U27_02895	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	Cation antiporter.	0.998
U27_02893	U27_06639	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	Cation antiporter.	0.995
U27_02893	U27_06640	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	Multiple resistance and pH regulation protein F.	0.985
U27_02893	U27_06642	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	Hypothetical protein.	0.985
U27_02893	U27_06643	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	Hypothetical protein.	0.978
U27_02893	U27_06644	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	Na+/H+ antiporter MnhB subunit-related protein.	0.993
U27_02893	U27_06645	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	NADH-ubiquinone oxidoreductase chain 4L.	0.993
U27_02893	U27_06646	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	NADH/Ubiquinone/plastoquinone (Complex I).	0.993
U27_02895	U27_02886	Cation antiporter.	NADH dehydrogenase (Quinone).	0.994
U27_02895	U27_02893	Cation antiporter.	Monovalent cation/proton antiporter, MnhG/PhaG subunit.	0.998

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.631

expected number of edges:

21

PPI enrichment p-value:

0.00195

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019439

Aromatic compound catabolic process

8 of 44

1.63

2.89

2.49e-09

GO:0009056

Catabolic process

9 of 136

1.19

1.57

1.11e-07

GO:0044270

Cellular nitrogen compound catabolic process

3 of 29

1.38

0.75

0.0230

GO:0046700

Heterocycle catabolic process

3 of 32

1.34

0.7

0.0278

GO:0044281

Small molecule metabolic process

11 of 523

0.69

0.65

6.89e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051537

2 iron, 2 sulfur cluster binding

4 of 9

2.02

2.05

7.01e-05

GO:0071949

FAD binding

3 of 6

2.07

1.57

0.00089

GO:0016491

Oxidoreductase activity

8 of 247

0.88

0.78

0.00029

GO:0043167

Ion binding

9 of 681

0.49

0.33

0.0247

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2554

Aromatic compound catabolic process

8 of 16

2.07

4.97

1.35e-12

CL:2556

CO dehydrogenase flavoprotein, C-terminal, and Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

6 of 7

2.3

4.57

3.52e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

4 of 90

1.02

0.59

0.0257

map01120

Microbial metabolism in diverse environments

6 of 236

0.78

0.48

0.0225

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01799

[2Fe-2S] binding domain

3 of 3

2.37

1.77

0.00047

PF00941

FAD binding domain in molybdopterin dehydrogenase

3 of 3

2.37

1.77

0.00047

PF00111

2Fe-2S iron-sulfur cluster binding domain

3 of 5

2.15

1.72

0.00047

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036683

CO dehydrogenase flavoprotein, C-terminal domain superfamily

4 of 4

2.37

2.53

1.44e-05

IPR005107

CO dehydrogenase flavoprotein, C-terminal

4 of 4

2.37

2.53

1.44e-05

IPR036884

[2Fe-2S]-binding domain superfamily

3 of 3

2.37

1.79

0.00044

IPR002888

[2Fe-2S]-binding

3 of 3

2.37

1.79

0.00044

IPR002346

Molybdopterin dehydrogenase, FAD-binding

3 of 3

2.37

1.79

0.00044

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01092

CO dehydrogenase flavoprotein C-terminal domain

3 of 3

2.37

2.07

0.00012

SM01008

Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

2 of 5

1.97

0.92

0.0177

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