SMG27601.1 protein (Agreia pratensis) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SMG27601.1

Uncharacterized protein. (1147 aa)

Predicted Functional Partners:

SMG27597.1

0.768

SMG35905.1

0.532

SMG24869.1

0.497

SMG27593.1

0.457

SMG42465.1

0.457

SMG42123.1

0.426

SMG35676.1

0.417

Your Current Organism:

Agreia pratensis

NCBI taxonomy Id: 150121
Other names: A. pratensis, Agreia pratensis (Behrendt et al. 2002) Schumann et al. 2003, DSM 14246, JCM 12145, LMG 21000, LMG:21000, NBRC 103054, Subtercola pratensis, Subtercola pratensis Behrendt et al. 2002, Subtercola sp. P229/10, VKM Ac-2510, strain P 229/10

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SMG24869.1	SMG27601.1	SAMN06296010_1206	SAMN06296010_1432	N-6 DNA Methylase.	Uncharacterized protein.	0.497
SMG27593.1	SMG27597.1	SAMN06296010_1430	SAMN06296010_1431	Predicted arabinose efflux permease, MFS family; Manually curated.	Predicted arabinose efflux permease, MFS family.	0.460
SMG27593.1	SMG27601.1	SAMN06296010_1430	SAMN06296010_1432	Predicted arabinose efflux permease, MFS family; Manually curated.	Uncharacterized protein.	0.457
SMG27597.1	SMG27593.1	SAMN06296010_1431	SAMN06296010_1430	Predicted arabinose efflux permease, MFS family.	Predicted arabinose efflux permease, MFS family; Manually curated.	0.460
SMG27597.1	SMG27601.1	SAMN06296010_1431	SAMN06296010_1432	Predicted arabinose efflux permease, MFS family.	Uncharacterized protein.	0.768
SMG27601.1	SMG24869.1	SAMN06296010_1432	SAMN06296010_1206	Uncharacterized protein.	N-6 DNA Methylase.	0.497
SMG27601.1	SMG27593.1	SAMN06296010_1432	SAMN06296010_1430	Uncharacterized protein.	Predicted arabinose efflux permease, MFS family; Manually curated.	0.457
SMG27601.1	SMG27597.1	SAMN06296010_1432	SAMN06296010_1431	Uncharacterized protein.	Predicted arabinose efflux permease, MFS family.	0.768
SMG27601.1	SMG35676.1	SAMN06296010_1432	SAMN06296010_2071	Uncharacterized protein.	Uncharacterized membrane protein YgcG, contains a TPM-fold domain.	0.417
SMG27601.1	SMG35905.1	SAMN06296010_1432	SAMN06296010_2088	Uncharacterized protein.	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains.	0.532
SMG27601.1	SMG42123.1	SAMN06296010_1432	SAMN06296010_2703	Uncharacterized protein.	Uncharacterized membrane protein YeiB.	0.426
SMG27601.1	SMG42465.1	SAMN06296010_1432	SAMN06296010_2732	Uncharacterized protein.	Superfamily I DNA or RNA helicase.	0.457
SMG35676.1	SMG27601.1	SAMN06296010_2071	SAMN06296010_1432	Uncharacterized membrane protein YgcG, contains a TPM-fold domain.	Uncharacterized protein.	0.417
SMG35905.1	SMG27601.1	SAMN06296010_2088	SAMN06296010_1432	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains.	Uncharacterized protein.	0.532
SMG42123.1	SMG27601.1	SAMN06296010_2703	SAMN06296010_1432	Uncharacterized membrane protein YeiB.	Uncharacterized protein.	0.426
SMG42465.1	SMG27601.1	SAMN06296010_2732	SAMN06296010_1432	Superfamily I DNA or RNA helicase.	Uncharacterized protein.	0.457

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

20

PPI enrichment p-value:

2.86e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 62

1.51

1.91

6.21e-06

GO:0000160

Phosphorelay signal transduction system

5 of 52

1.51

1.66

5.65e-05

GO:0050794

Regulation of cellular process

9 of 253

1.08

1.24

2.38e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

5 of 25

1.83

2.27

8.43e-06

GO:0000155

Phosphorelay sensor kinase activity

4 of 24

1.75

1.79

0.00011

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 171

1.14

1.22

2.82e-05

GO:0016740

Transferase activity

9 of 591

0.71

0.61

0.00028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 579

0.61

0.36

0.0471

GO:0016021

Integral component of membrane

8 of 769

0.54

0.33

0.0471

GO:0016020

Membrane

9 of 1176

0.41

0.28

0.0471

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2148

Phosphorelay signal transduction system, and RNA polymerase sigma factor 54 interaction domain

11 of 41

1.96

6.07

1.09e-18

CL:2155

Mixed, incl. PAS domain, and Phosphoric diester hydrolase activity

8 of 21

2.11

5.5

6.46e-14

CL:2161

PAS-associated, C-terminal, and Bacterial chemotaxis

6 of 10

2.31

4.88

6.39e-11

CL:2163

Diguanylate cyclase, and Regulation of signaling

3 of 5

2.31

2.21

5.90e-05

CL:2215

Sigma-54 interaction domain, ATP-binding site 1, and PAS fold

3 of 7

2.16

2.01

0.00012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 277

1.08

1.42

8.29e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

4 of 74

1.26

0.79

0.0122

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001610

PAC motif

4 of 8

2.23

2.3

3.24e-05

IPR035965

PAS domain superfamily

4 of 10

2.13

2.26

3.27e-05

IPR000014

PAS domain

4 of 10

2.13

2.26

3.27e-05

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

4 of 17

1.9

1.92

9.67e-05

IPR005467

Histidine kinase domain

4 of 20

1.83

1.81

0.00014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

4 of 9

2.17

2.71

3.74e-06

SM00091

PAS domain

4 of 11

2.09

2.64

3.74e-06

SM00388

His Kinase A (phosphoacceptor) domain

4 of 17

1.9

2.31

1.03e-05

SM00387

Histidine kinase-like ATPases

4 of 22

1.79

2.1

1.92e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

2 of 5

2.13

1.25

0.0042

(more ...)

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