node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMG28966.1 | SMG42465.1 | SAMN06296010_1524 | SAMN06296010_2732 | ATP-dependent DNA helicase RecQ. | Superfamily I DNA or RNA helicase. | 0.867 |
SMG28966.1 | SMG43747.1 | SAMN06296010_1524 | SAMN06296010_2808 | ATP-dependent DNA helicase RecQ. | PIF1-like helicase. | 0.528 |
SMG28966.1 | SMG48425.1 | SAMN06296010_1524 | SAMN06296010_3322 | ATP-dependent DNA helicase RecQ. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.708 |
SMG28966.1 | recA | SAMN06296010_1524 | SAMN06296010_3095 | ATP-dependent DNA helicase RecQ. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.910 |
SMG28966.1 | topA | SAMN06296010_1524 | SAMN06296010_0467 | ATP-dependent DNA helicase RecQ. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.882 |
SMG42465.1 | SMG28966.1 | SAMN06296010_2732 | SAMN06296010_1524 | Superfamily I DNA or RNA helicase. | ATP-dependent DNA helicase RecQ. | 0.867 |
SMG42465.1 | SMG42471.1 | SAMN06296010_2732 | SAMN06296010_2733 | Superfamily I DNA or RNA helicase. | DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily. | 0.992 |
SMG42465.1 | SMG43747.1 | SAMN06296010_2732 | SAMN06296010_2808 | Superfamily I DNA or RNA helicase. | PIF1-like helicase. | 0.553 |
SMG42465.1 | SMG48425.1 | SAMN06296010_2732 | SAMN06296010_3322 | Superfamily I DNA or RNA helicase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.860 |
SMG42465.1 | recA | SAMN06296010_2732 | SAMN06296010_3095 | Superfamily I DNA or RNA helicase. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.828 |
SMG42465.1 | topA | SAMN06296010_2732 | SAMN06296010_0467 | Superfamily I DNA or RNA helicase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.688 |
SMG42471.1 | SMG42465.1 | SAMN06296010_2733 | SAMN06296010_2732 | DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily. | Superfamily I DNA or RNA helicase. | 0.992 |
SMG42471.1 | SMG43747.1 | SAMN06296010_2733 | SAMN06296010_2808 | DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily. | PIF1-like helicase. | 0.851 |
SMG42471.1 | SMG48425.1 | SAMN06296010_2733 | SAMN06296010_3322 | DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.561 |
SMG42471.1 | recA | SAMN06296010_2733 | SAMN06296010_3095 | DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.559 |
SMG43747.1 | SMG28966.1 | SAMN06296010_2808 | SAMN06296010_1524 | PIF1-like helicase. | ATP-dependent DNA helicase RecQ. | 0.528 |
SMG43747.1 | SMG42465.1 | SAMN06296010_2808 | SAMN06296010_2732 | PIF1-like helicase. | Superfamily I DNA or RNA helicase. | 0.553 |
SMG43747.1 | SMG42471.1 | SAMN06296010_2808 | SAMN06296010_2733 | PIF1-like helicase. | DNA helicase-2 / ATP-dependent DNA helicase PcrA; Belongs to the helicase family. UvrD subfamily. | 0.851 |
SMG43747.1 | SMG43795.1 | SAMN06296010_2808 | SAMN06296010_2809 | PIF1-like helicase. | Hypothetical protein. | 0.558 |
SMG43747.1 | SMG48425.1 | SAMN06296010_2808 | SAMN06296010_3322 | PIF1-like helicase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.771 |